Literature DB >> 11128635

Fatty acid amide hydrolase substrate specificity.

D L Boger1, R A Fecik, J E Patterson, H Miyauchi, M P Patricelli, B F Cravatt.   

Abstract

Fatty acid amide hydrolase (FAAH), also referred to as oleamide hydrolase and anandamide amidohydrolase, is a serine hydrolase responsible for the degradation of endogenous oleamide and anandamide, fatty acid amides that function as chemical messengers. FAAH hydrolyzes a range of fatty acid amides, and the present study examines the relative rates of hydrolysis of a variety of natural and unnatural fatty acid primary amide substrates using pure recombinant rat FAAH.

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Year:  2000        PMID： 11128635     DOI： 10.1016/s0960-894x(00)00528-x

Source DB:  PubMed          Journal:  Bioorg Med Chem Lett        ISSN： 0960-894X            Impact factor:   2.823


  45 in total

1.  Development of highly sensitive fluorescent assays for fatty acid amide hydrolase.

Authors:  Huazhang Huang; Kosuke Nishi; Hsing-Ju Tsai; Bruce D Hammock
Journal:  Anal Biochem       Date:  2006-12-20       Impact factor: 3.365

2.  Microglia produce and hydrolyze palmitoylethanolamide.

Authors:  Giulio G Muccioli; Nephi Stella
Journal:  Neuropharmacology       Date:  2007-06-02       Impact factor: 5.250

3.  Exploration of a fundamental substituent effect of alpha-ketoheterocycle enzyme inhibitors: Potent and selective inhibitors of fatty acid amide hydrolase.

Authors:  Jessica K DeMartino; Joie Garfunkle; Dustin G Hochstatter; Benjamin F Cravatt; Dale L Boger
Journal:  Bioorg Med Chem Lett       Date:  2008-06-28       Impact factor: 2.823

4.  Potent and selective alpha-ketoheterocycle-based inhibitors of the anandamide and oleamide catabolizing enzyme, fatty acid amide hydrolase.

Authors:  F Anthony Romero; Wu Du; Inkyu Hwang; Thomas J Rayl; F Scott Kimball; Donmienne Leung; Heather S Hoover; Richard L Apodaca; J Guy Breitenbucher; Benjamin F Cravatt; Dale L Boger
Journal:  J Med Chem       Date:  2007-02-06       Impact factor: 7.446

5.  Targeting Fatty-Acid Amide Hydrolase with Prodrugs for CNS-Selective Therapy.

Authors:  J Matthew Meinig; Skylar J Ferrara; Tania Banerji; Tapasree Banerji; Hannah S Sanford-Crane; Dennis Bourdette; Thomas S Scanlan
Journal:  ACS Chem Neurosci       Date:  2017-08-18       Impact factor: 4.418

6.  Delineation of a fundamental alpha-ketoheterocycle substituent effect for use in the design of enzyme inhibitors.

Authors:  F Anthony Romero; Inkyu Hwang; Dale L Boger
Journal:  J Am Chem Soc       Date:  2006-11-01       Impact factor: 15.419

7.  Synthesis of phenoxyacyl-ethanolamides and their effects on fatty acid amide hydrolase activity.

Authors:  Lionel Faure; Subbiah Nagarajan; Hyeondo Hwang; Christa L Montgomery; Bibi Rafeiza Khan; George John; Peter Koulen; Elison B Blancaflor; Kent D Chapman
Journal:  J Biol Chem       Date:  2014-02-20       Impact factor: 5.157

8.  Rational design of fatty acid amide hydrolase inhibitors that act by covalently bonding to two active site residues.

Authors:  Katerina Otrubova; Monica Brown; Michael S McCormick; Gye W Han; Scott T O'Neal; Benjamin F Cravatt; Raymond C Stevens; Aron H Lichtman; Dale L Boger
Journal:  J Am Chem Soc       Date:  2013-04-12       Impact factor: 15.419

9.  N-acylethanolamines are metabolized by lipoxygenase and amidohydrolase in competing pathways during cottonseed imbibition.

Authors:  Rhidaya Shrestha; Minke A Noordermeer; Marcelis van der Stelt; Gerrit A Veldink; Kent D Chapman
Journal:  Plant Physiol       Date:  2002-09       Impact factor: 8.340

10.  X-ray crystallographic analysis of alpha-ketoheterocycle inhibitors bound to a humanized variant of fatty acid amide hydrolase.

Authors:  Mauro Mileni; Joie Garfunkle; Cyrine Ezzili; F Scott Kimball; Benjamin F Cravatt; Raymond C Stevens; Dale L Boger
Journal:  J Med Chem       Date:  2010-01-14       Impact factor: 7.446
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