Literature DB >> 11128634

Improved synthesis of the iodine-free thyromimetic GC-1.

G Chiellini1, N H Nguyen, H A Yoshihara, T S Scanlan.   

Abstract

Synthesis of the TRbeta-selective thyromimetic GC-1 has been improved using methoxymethyl (MOM) and triisopropylsilyl (TiPS) substituents as phenolic protecting groups. The new synthetic route is adaptable to analogue design.

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Year:  2000        PMID： 11128634     DOI： 10.1016/s0960-894x(00)00531-x

Source DB:  PubMed          Journal:  Bioorg Med Chem Lett        ISSN： 0960-894X            Impact factor:   2.823


  10 in total

Review 1.  GC-1: A Thyromimetic With Multiple Therapeutic Applications in Liver Disease.

Authors:  Amedeo Columbano; Grazia Chiellini; Marta Anna Kowalik
Journal:  Gene Expr       Date:  2017-06-13

2.  T3 Induces Both Markers of Maturation and Aging in Pancreatic β-Cells.

Authors:  Cristina Aguayo-Mazzucato; Terence B Lee; Michelle Matzko; Amanda DiIenno; Habib Rezanejad; Preeti Ramadoss; Thomas Scanlan; Ann Marie Zavacki; P Reed Larsen; Anthony Hollenberg; Clark Colton; Arun Sharma; Susan Bonner-Weir
Journal:  Diabetes       Date:  2018-04-06       Impact factor: 9.461

3.  A functionally orthogonal ligand-receptor pair created by targeting the allosteric mechanism of the thyroid hormone receptor.

Authors:  A Quamrul Hassan; John T Koh
Journal:  J Am Chem Soc       Date:  2006-07-12       Impact factor: 15.419

4.  New synthetic routes to thyroid hormone analogs: d6-sobetirome, 3H-sobetirome, and the antagonist NH-3.

Authors:  Andrew T Placzek; Thomas S Scanlan
Journal:  Tetrahedron       Date:  2015-05-20       Impact factor: 2.457

5.  Targeting Fatty-Acid Amide Hydrolase with Prodrugs for CNS-Selective Therapy.

Authors:  J Matthew Meinig; Skylar J Ferrara; Tania Banerji; Tapasree Banerji; Hannah S Sanford-Crane; Dennis Bourdette; Thomas S Scanlan
Journal:  ACS Chem Neurosci       Date:  2017-08-18       Impact factor: 4.418

6.  Selective thyroid receptor modulation by GC-1 reduces serum lipids and stimulates steps of reverse cholesterol transport in euthyroid mice.

Authors:  Lisen Johansson; Mats Rudling; Thomas S Scanlan; Thomas Lundåsen; Paul Webb; John Baxter; Bo Angelin; Paolo Parini
Journal:  Proc Natl Acad Sci U S A       Date:  2005-07-08       Impact factor: 11.205

7.  Comparative molecular field analysis and synthetic validation of a hydroxyamide-propofol binding and functional block of neuronal voltage-dependent sodium channels.

Authors:  Milton L Brown; Hilary A Eidam; Mikell Paige; Paulianda J Jones; Manoj K Patel
Journal:  Bioorg Med Chem       Date:  2008-12-03       Impact factor: 3.641

Review 8.  Sobetirome: a case history of bench-to-clinic drug discovery and development.

Authors:  Thomas S Scanlan
Journal:  Heart Fail Rev       Date:  2008-11-11       Impact factor: 4.214

9.  Structural basis of GC-1 selectivity for thyroid hormone receptor isoforms.

Authors:  Lucas Bleicher; Ricardo Aparicio; Fabio M Nunes; Leandro Martinez; Sandra M Gomes Dias; Ana Carolina Migliorini Figueira; Maria Auxiliadora Morim Santos; Walter H Venturelli; Rosangela da Silva; Paulo Marcos Donate; Francisco Ar Neves; Luiz A Simeoni; John D Baxter; Paul Webb; Munir S Skaf; Igor Polikarpov
Journal:  BMC Struct Biol       Date:  2008-01-31

10.  Thyroid hormone inhibits lung fibrosis in mice by improving epithelial mitochondrial function.

Authors:  Guoying Yu; Argyris Tzouvelekis; Rong Wang; Jose D Herazo-Maya; Gabriel H Ibarra; Anup Srivastava; Joao Pedro Werneck de Castro; Giuseppe DeIuliis; Farida Ahangari; Tony Woolard; Nachelle Aurelien; Rafael Arrojo E Drigo; Ye Gan; Morven Graham; Xinran Liu; Robert J Homer; Thomas S Scanlan; Praveen Mannam; Patty J Lee; Erica L Herzog; Antonio C Bianco; Naftali Kaminski
Journal:  Nat Med       Date:  2017-12-04       Impact factor: 53.440
  10 in total

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