Literature DB >> 11128632

2,4,5-Trisubstituted imidazoles: novel nontoxic modulators of P-glycoprotein mediated multidrug resistance. Part 1.

S Sarshar1, C Zhang, E J Moran, S Krane, J C Rodarte, K D Benbatoul, R Dixon, A M Mjalli.   

Abstract

N-4,5-Di-(4-dialkylamino)phenyl imidazoles (A) are potent modulators of P-glycoprotein mediated multidrug resistance. This manuscript describes the discovery and lead optimization of this novel class of inhibitors.

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Year:  2000        PMID： 11128632     DOI： 10.1016/s0960-894x(00)00520-5

Source DB:  PubMed          Journal:  Bioorg Med Chem Lett        ISSN： 0960-894X            Impact factor:   2.823


  2 in total

1.  A novel approach for predicting P-glycoprotein (ABCB1) inhibition using molecular interaction fields.

Authors:  Fabio Broccatelli; Emanuele Carosati; Annalisa Neri; Maria Frosini; Laura Goracci; Tudor I Oprea; Gabriele Cruciani
Journal:  J Med Chem       Date:  2011-02-22       Impact factor: 7.446

2.  Pharmacophore mapping of a series of pyrrolopyrimidines, indolopyrimidines and their congeners as multidrug-resistance-associated protein (MRP1) modulators.

Authors:  Nilesh R Tawari; Seema Bag; Mariam S Degani
Journal:  J Mol Model       Date:  2008-07-11       Impact factor: 1.810
  2 in total

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