OBJECTIVE: To study whether weight reducing treatment modulates serum concentration of TNF-alpha and two soluble TNF-alpha receptors in obese subjects. SUBJECTS AND MEASUREMENTS: Serum concentrations of TNF-alpha and two soluble receptors (sTNF-R1, sTNF-R2), plasma glucose, insulin, total cholesterol, HDL-cholesterol and triglicerides were measured in 27 obese subjects (age 48 +/- 12y, body mass index (BMI): 36 +/- 6 kg/m2) before and after 3 months weight reducing treatment consisted of a diet & 1,000 kcal/day and physical exercises. RESULTS: The mean loss of weight during 3 months' treatment was 9.3 +/- 3.3 kg. The serum concentration of TNF-alpha decreased after weight loss and at the same time both of the receptors (sTNF-R1,sTNF-R2) increased significantly. CONCLUSION: The observed decrease of the serum concentration of TNF-alpha and the increase in both TNF soluble receptors after weight reducing treatment in obese subjects, may be a counter-regulation preventing further weight loss.
OBJECTIVE: To study whether weight reducing treatment modulates serum concentration of TNF-alpha and two soluble TNF-alpha receptors in obese subjects. SUBJECTS AND MEASUREMENTS: Serum concentrations of TNF-alpha and two soluble receptors (sTNF-R1, sTNF-R2), plasma glucose, insulin, total cholesterol, HDL-cholesterol and triglicerides were measured in 27 obese subjects (age 48 +/- 12y, body mass index (BMI): 36 +/- 6 kg/m2) before and after 3 months weight reducing treatment consisted of a diet & 1,000 kcal/day and physical exercises. RESULTS: The mean loss of weight during 3 months' treatment was 9.3 +/- 3.3 kg. The serum concentration of TNF-alpha decreased after weight loss and at the same time both of the receptors (sTNF-R1,sTNF-R2) increased significantly. CONCLUSION: The observed decrease of the serum concentration of TNF-alpha and the increase in both TNF soluble receptors after weight reducing treatment in obese subjects, may be a counter-regulation preventing further weight loss.
Authors: Núria Vilarrasa; Joan Vendrell; Javier Maravall; Iñaki Elío; Esther Solano; Patricia San José; Isabel García; Núria Virgili; Juan Soler; José Manuel Gómez Journal: Endocrine Date: 2010-07-23 Impact factor: 3.633
Authors: Danuta Rość; Przemysław Adamczyk; Joanna Boinska; Robert Szafkowski; Irena Ponikowska; Katarzyna Stankowska; Barbara Góralczyk; Barbara Ruszkowska-Ciastek Journal: J Zhejiang Univ Sci B Date: 2015-05 Impact factor: 3.066
Authors: Magdalena Olszanecka-Glinianowicz; Barbara Zahorska-Markiewicz; Piotr Kocełak; Joanna Janowska; Elzbieta Semik-Grabarczyk; Tomasz Wikarek; Wojciech Gruszka; Piotr Dabrowski Journal: Mediators Inflamm Date: 2009-06-29 Impact factor: 4.711