| Literature DB >> 11126297 |
J M Salvino1, N V Kumar, E Orton, J Airey, T Kiesow, K Crawford, R Mathew, P Krolikowski, M Drew, D Engers, D Krolikowski, T Herpin, M Gardyan, G McGeehan, R Labaudiniere.
Abstract
A new tetrafluorophenol activated resin that facilitates the use of 19F NMR to quantitate loading is presented. This new resin provides a useful tool for acylation, and a novel activated polymeric sulfonate ester to generate sulfonamides. This activated resin reacts with a wide scope of N-nucleophiles including primary and secondary amines, and anilines. This new activated resin methodology provides a powerful tool for pure single-compound library synthesis.Entities:
Year: 2000 PMID： 11126297 DOI： 10.1021/cc0000491
Source DB: PubMed Journal: J Comb Chem ISSN： 1520-4766