Literature DB >> 1112598

Changes in the mitotic cycle induced by alpha-solanine.

D Kirk, U Mittwoch.   

Abstract

Low concentrations of alpha-solanine stimulated the growth of cultured human fibroblasts, while higher concentrations (greater 30 mug ml-1) had a markedly inhibitory effect. Autoradiographic studies indicated that the stimulation of cell growth was due to a shortening of the G1 phase. Feulgen microdensitometry of cells treated with high doses of alpha-solanine revealed an abnormal accumulation of cells in G2. The response of cultured human fibroblasts to low doses of alpha-solanine is comparable to that of sex hormones on target tissues. It is concluded that by virtue of either its stimulatory or its inhibitory effect on cell growth, alpha-solanine could act as a human teratogen.

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Year:  1975        PMID： 1112598     DOI： 10.1007/bf00278436

Source DB:  PubMed          Journal:  Humangenetik        ISSN： 0018-7348


  16 in total

1.  Cell population kinetics in the intestinal epithelium of the mouse.

Authors:  H QUASTLER; F G SHERMAN
Journal:  Exp Cell Res       Date:  1959-06       Impact factor: 3.905

2.  Possible mechanisms of human teratogenesis by imperfect potato.

Authors:  I Gal
Journal:  Humangenetik       Date:  1973-09-20

3.  Stimulation of adenyl cyclase in pupal wing epidermis by -ecdysone.

Authors:  S W Applebaum; L I Gilbert
Journal:  Dev Biol       Date:  1972-02       Impact factor: 3.582

4.  The cyclic AMP system in normal and psoriatic epidermis.

Authors:  J J Voorhees; E A Duell; L J Bass; J A Powell; E R Harrell
Journal:  J Invest Dermatol       Date:  1972-07       Impact factor: 8.551

5.  Pharmacology of solanine.

Authors:  K Nishie; M R Gumbmann; A C Keyl
Journal:  Toxicol Appl Pharmacol       Date:  1971-05       Impact factor: 4.219

6.  Comparison of cell cycle time in normal and trisomic cells.

Authors:  G R Paton; M F Silver; A C Allison
Journal:  Humangenetik       Date:  1974

Review 7.  Cyclic AMP.

Authors:  G A Robison; R W Butcher; E W Sutherland
Journal:  Annu Rev Biochem       Date:  1968       Impact factor: 23.643

8.  Migration and proliferation of diploid human fibroblasts following "wounding" of confluent monolayers.

Authors:  E C Raff; J C Houck
Journal:  J Cell Physiol       Date:  1969-12       Impact factor: 6.384

9.  The effect of chlorimipramine on DNA synthesis and mitosis in cultured human cells.

Authors:  U Mittwoch; D Wilkie
Journal:  Br J Exp Pathol       Date:  1971-04

10.  Are potatoes teratogenic for experimental animals?

Authors:  C A Swinyard; S Chaube
Journal:  Teratology       Date:  1973-12
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  2 in total

1.  A Reliable and Reproducible Model for Assessing the Effect of Different Concentrations of α-Solanine on Rat Bone Marrow Mesenchymal Stem Cells.

Authors:  Adriana Ordóñez-Vásquez; Lorenza Jaramillo-Gómez; Camilo Duran-Correa; Erandi Escamilla-García; Myriam Angélica De la Garza-Ramos; Fernando Suárez-Obando
Journal:  Bone Marrow Res       Date:  2017-10-22

2.  Solanum tuberosum and Lycopersicon esculentum Leaf Extracts and Single Metabolites Affect Development and Reproduction of Drosophila melanogaster.

Authors:  Emanuela Ventrella; Zbigniew Adamski; Ewa Chudzińska; Mariola Miądowicz-Kobielska; Paweł Marciniak; Ender Büyükgüzel; Kemal Büyükgüzel; Meltem Erdem; Patrizia Falabella; Laura Scrano; Sabino Aurelio Bufo
Journal:  PLoS One       Date:  2016-05-23       Impact factor: 3.240
  2 in total

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