D Urban1, W Irwin, M Kirk, M A Markiewicz, R Myers, M Smith, H Weiss, W E Grizzle, S Barnes. 1. Division of Urology, Departments of Surgery, Pathology and Pharmacology and Toxicology, and Biostatistics Unit and Mass Spectrometry Shared Facility, Comprehensive Cancer Center, University of Alabama at Birmingham, USA.
Abstract
PURPOSE: We performed a randomized double-blind crossover pilot study in elderly men with elevated prostate specific antigen (PSA) on the effects of the daily consumption of 2 soy beverages, each containing 20 gm. of isolated soy protein, on the isoflavone concentration in blood and urine, and on the 3 serum biomarkers cholesterol, PSA and the soluble p105 component of the p185erbB-2 proto-oncogene. MATERIALS AND METHODS: A total of 34 men supplemented their diet by consuming 1 of 2 soy protein beverages assigned randomly twice daily for a 6-week period. In a second 6-week period they consumed the other soy protein beverage. The beverage ISP+ provided 42 mg. of genistein and 27 mg. of daidzein daily, whereas the other beverage, ISP-, provided only 2.1 and 1.3 mg. of these isoflavones daily, respectively. Blood and 24-hour urine samples were obtained before the study, at 2-week intervals during the study and 2 weeks after study completion. RESULTS:ISP+ and to a lesser extent ISP- substantially increased the serum concentration and urinary output of the isoflavones and their metabolites. Serum cholesterol was significantly decreased by ISP+ irrespective of the order in which the 2 soy beverages were administered and in apparent correlation with the total isoflavone concentration. There was no significant effect of the soy beverages on serum PSA and p105erbB-2 values. CONCLUSIONS: This study reveals that short-term exposure of elderly men with elevated serum PSA values tosoy protein containing isoflavones decreases serum cholesterol but not the serum biomarkers PSA and p105erbB-2.
RCT Entities:
PURPOSE: We performed a randomized double-blind crossover pilot study in elderly men with elevated prostate specific antigen (PSA) on the effects of the daily consumption of 2 soy beverages, each containing 20 gm. of isolated soy protein, on the isoflavone concentration in blood and urine, and on the 3 serum biomarkers cholesterol, PSA and the soluble p105 component of the p185erbB-2 proto-oncogene. MATERIALS AND METHODS: A total of 34 men supplemented their diet by consuming 1 of 2 soy protein beverages assigned randomly twice daily for a 6-week period. In a second 6-week period they consumed the other soy protein beverage. The beverage ISP+ provided 42 mg. of genistein and 27 mg. of daidzein daily, whereas the other beverage, ISP-, provided only 2.1 and 1.3 mg. of these isoflavones daily, respectively. Blood and 24-hour urine samples were obtained before the study, at 2-week intervals during the study and 2 weeks after study completion. RESULTS: ISP+ and to a lesser extent ISP- substantially increased the serum concentration and urinary output of the isoflavones and their metabolites. Serum cholesterol was significantly decreased by ISP+ irrespective of the order in which the 2 soy beverages were administered and in apparent correlation with the total isoflavone concentration. There was no significant effect of the soy beverages on serum PSA and p105erbB-2 values. CONCLUSIONS: This study reveals that short-term exposure of elderly men with elevated serum PSA values to soy protein containing isoflavones decreases serum cholesterol but not the serum biomarkers PSA and p105erbB-2.
Authors: Maarten C Bosland; Ikuko Kato; Anne Zeleniuch-Jacquotte; Joanne Schmoll; Erika Enk Rueter; Jonathan Melamed; Max Xiangtian Kong; Virgilia Macias; Andre Kajdacsy-Balla; L H Lumey; Hui Xie; Weihua Gao; Paul Walden; Herbert Lepor; Samir S Taneja; Carla Randolph; Michael J Schlicht; Hiroko Meserve-Watanabe; Ryan J Deaton; Joanne A Davies Journal: JAMA Date: 2013-07-10 Impact factor: 56.272
Authors: M Tanaka; K Fujimoto; Y Chihara; K Torimoto; T Yoneda; N Tanaka; A Hirayama; N Miyanaga; H Akaza; Y Hirao Journal: Prostate Cancer Prostatic Dis Date: 2009-07-14 Impact factor: 5.554