The serotonin 5-HT(2A) receptor subtype does not mediate apomorphine-induced aggressive behaviour in male Wistar rats.

We have studied the effect of the 5-HT(2A) receptor antagonists on apomorphine-induced aggressive behaviour in male Wistar rats. In acute behavioural experiments with apomorphine-pretreated (1.0 mg/kg, s.c., once daily, 2 weeks) animals, risperidone (0.5 and 1.0 mg/kg) inhibited aggressive behaviour, but ketanserin and ritanserin (0.5-5. 0 mg/kg) had no effect on the latency and intensity of aggressive behaviour. Concomitant risperidone (0.5 mg/kg) and haloperidol (0.03 and 0.3 mg/kg) administration blocked aggressive behaviour completely. In conclusion, our experiments confirm that inhibition of the apomorphine-induced aggressive behaviour is elicited by drugs with dopamine (DA) but not with 5-HT(2A) antagonistic activity. Moreover, it may be concluded that the serotonin 5-HT(2A) receptor subtype does not alter the DA-mediated behaviour.