Literature DB >> 11123866

Genetic factors in ovarian carcinoma.

A J Li1, B Y Karlan.   

Abstract

Recent evidence indicates that inherited and acquired genetic mutations are the driving force behind carcinogenesis and cellular transformation. This review examines a number of proto-oncogenes and tumor suppressor genes that are associated with ovarian carcinomas, including p53, BRCA1, and BRCA2; mismatch repair genes such as hMSH2 and hMLH1; and PTEN, HER-2/neu, K-ras, fms, and AKT2. Novel genes recently implicated in ovarian tumorigenesis are discussed, including NOEY2, OVCA1, and PIK3CA. Although no singular gene alteration has been shown to initiate transformation in the ovarian epithelium, elucidation of the complex molecular and cellular mechanisms involving these known gene mutations may result in new clinical management strategies.

Entities:  

Mesh：

Substances：

Year:  2001        PMID： 11123866     DOI： 10.1007/s11912-001-0039-y

Source DB:  PubMed          Journal:  Curr Oncol Rep        ISSN： 1523-3790            Impact factor:   5.075


  40 in total

1.  Contribution of c-erbB-2 and topoisomerase IIalpha to chemoresistance in ovarian cancer.

Authors:  J G Hengstler; J Lange; A Kett; N Dornhöfer; R Meinert; M Arand; P G Knapstein; R Becker; F Oesch; B Tanner
Journal:  Cancer Res       Date:  1999-07-01       Impact factor: 12.701

Review 2.  Trastuzumab, a recombinant DNA-derived humanized monoclonal antibody, a novel agent for the treatment of metastatic breast cancer.

Authors:  M M Goldenberg
Journal:  Clin Ther       Date:  1999-02       Impact factor: 3.393

3.  Increased frequency of TP53 mutations in BRCA1 and BRCA2 ovarian tumours.

Authors:  S J Ramus; L G Bobrow; P D Pharoah; D S Finnigan; A Fishman; M Altaras; P A Harrington; S A Gayther; B A Ponder; L S Friedman
Journal:  Genes Chromosomes Cancer       Date:  1999-06       Impact factor: 5.006

4.  Accumulation of p53 protein is frequent in ovarian cancers associated with BRCA1 and BRCA2 germline mutations.

Authors:  R P Zweemer; P A Shaw; R M Verheijen; A Ryan; A Berchuck; B A Ponder; H Risch; J R McLaughlin; S A Narod; F H Menko; P Kenemans; I J Jacobs
Journal:  J Clin Pathol       Date:  1999-05       Impact factor: 3.411

5.  Variation of risks of breast and ovarian cancer associated with different germline mutations of the BRCA2 gene.

Authors:  S A Gayther; J Mangion; P Russell; S Seal; R Barfoot; B A Ponder; M R Stratton; D Easton
Journal:  Nat Genet       Date:  1997-01       Impact factor: 38.330

6.  Correlation of TP53 mutations and p53 expression in ovarian tumors.

Authors:  R A DiCioccio; B A Werness; R Peng; H J Allen; M S Piver
Journal:  Cancer Genet Cytogenet       Date:  1998-09

7.  NOEY2 (ARHI), an imprinted putative tumor suppressor gene in ovarian and breast carcinomas.

Authors:  Y Yu; F Xu; H Peng; X Fang; S Zhao; Y Li; B Cuevas; W L Kuo; J W Gray; M Siciliano; G B Mills; R C Bast
Journal:  Proc Natl Acad Sci U S A       Date:  1999-01-05       Impact factor: 11.205

8.  Mutation of the PTEN tumor suppressor gene is not a feature of ovarian cancers.

Authors:  G L Maxwell; J I Risinger; B Tong; H Shaw; J C Barrett; A Berchuck; P A Futreal
Journal:  Gynecol Oncol       Date:  1998-07       Impact factor: 5.482

9.  Molecular alterations of the AKT2 oncogene in ovarian and breast carcinomas.

Authors:  A Bellacosa; D de Feo; A K Godwin; D W Bell; J Q Cheng; D A Altomare; M Wan; L Dubeau; G Scambia; V Masciullo; G Ferrandina; P Benedetti Panici; S Mancuso; G Neri; J R Testa
Journal:  Int J Cancer       Date:  1995-08-22       Impact factor: 7.396

10.  Identification of two candidate tumor suppressor genes on chromosome 17p13.3.

Authors:  D C Schultz; L Vanderveer; D B Berman; T C Hamilton; A J Wong; A K Godwin
Journal:  Cancer Res       Date:  1996-05-01       Impact factor: 12.701
View more
  9 in total

Review 1.  Second malignancies among elderly survivors of cancer.

Authors:  Ari M VanderWalde; Arti Hurria
Journal:  Oncologist       Date:  2011-10-31

Review 2.  BRCAness: finding the Achilles heel in ovarian cancer.

Authors:  Georgios Rigakos; Evangelia Razis
Journal:  Oncologist       Date:  2012-06-06

3.  Subacute onset of deafness and vertigo in a patient with leptomeningeal metastasis from ovarian cancer.

Authors:  Roberta Vitaliani; Marco Spinazzi; Anna Rosa Del Mistro; Renzo Manara; Bruno Tavolato; Domenico Marco Bonifati
Journal:  Neurol Sci       Date:  2009-01-16       Impact factor: 3.307

4.  Secondary BRCA1 mutations in BRCA1-mutated ovarian carcinomas with platinum resistance.

Authors:  Elizabeth M Swisher; Wataru Sakai; Beth Y Karlan; Kaitlyn Wurz; Nicole Urban; Toshiyasu Taniguchi
Journal:  Cancer Res       Date:  2008-04-15       Impact factor: 12.701

5.  Loss of diphthamide pre-activates NF-κB and death receptor pathways and renders MCF7 cells hypersensitive to tumor necrosis factor.

Authors:  Sebastian Stahl; Ana Rita da Silva Mateus Seidl; Axel Ducret; Sabine Kux van Geijtenbeek; Sven Michel; Tomas Racek; Fabian Birzele; Alexander K Haas; Ruediger Rueger; Michael Gerg; Gerhard Niederfellner; Ira Pastan; Ulrich Brinkmann
Journal:  Proc Natl Acad Sci U S A       Date:  2015-08-10       Impact factor: 11.205

6.  Secondary mutations as a mechanism of cisplatin resistance in BRCA2-mutated cancers.

Authors:  Wataru Sakai; Elizabeth M Swisher; Beth Y Karlan; Mukesh K Agarwal; Jake Higgins; Cynthia Friedman; Emily Villegas; Céline Jacquemont; Daniel J Farrugia; Fergus J Couch; Nicole Urban; Toshiyasu Taniguchi
Journal:  Nature       Date:  2008-02-10       Impact factor: 49.962

7.  Chromosome 3 anomalies investigated by genome wide SNP analysis of benign, low malignant potential and low grade ovarian serous tumours.

Authors:  Ashley H Birch; Suzanna L Arcand; Kathleen K Oros; Kurosh Rahimi; A Kevin Watters; Diane Provencher; Celia M Greenwood; Anne-Marie Mes-Masson; Patricia N Tonin
Journal:  PLoS One       Date:  2011-12-06       Impact factor: 3.240

8.  Central nervous system metastasis in epithelial ovarian carcinoma: a case report and literature review.

Authors:  Fereshteh Fakour; Hadi Hajizadeh Fallah; Sina Khajeh Jahromi; Parham Porteghali
Journal:  J Family Reprod Health       Date:  2015-03

9.  MiR-200c sensitizes Olaparib-resistant ovarian cancer cells by targeting Neuropilin 1.

Authors:  Enrica Vescarelli; Giulia Gerini; Francesca Megiorni; Eleni Anastasiadou; Paola Pontecorvi; Luciana Solito; Claudia De Vitis; Simona Camero; Claudia Marchetti; Rita Mancini; Pierluigi Benedetti Panici; Carlo Dominici; Ferdinando Romano; Antonio Angeloni; Cinzia Marchese; Simona Ceccarelli
Journal:  J Exp Clin Cancer Res       Date:  2020-01-02
  9 in total

北京卡尤迪生物科技股份有限公司 © 2022-2023.