| Literature DB >> 11123333 |
L Pricop1, P Redecha, J L Teillaud, J Frey, W H Fridman, C Sautès-Fridman, J E Salmon.
Abstract
Immune complex-mediated inflammatory responses are initiated by Fc gamma R on phagocytes. We report in this study that an inhibitory receptor, Fc gamma RIIb2, is expressed on circulating human monocytes, and when co-cross-linked with stimulatory Fc gamma R it down-regulates effector function. Fc gamma RIIb2 expression is increased by IL-4 and decreased by IFN-gamma, in contrast to the activating receptor, Fc gamma RIIa, which is increased by IFN-gamma and decreased by IL-4. Thus, Th1 and Th2 cytokines differentially regulate the opposing Fc gamma R systems, altering the balance of activating and inhibiting Fc gamma R. The detection and cytokine modulation of Fc gamma RIIb2 in human myeloid cells provide evidence of a negative regulator of immune complex-mediated responses in human phagocytes and offer a new approach to limit Ab-triggered inflammation in autoimmune disease.Entities:
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Year: 2001 PMID： 11123333 DOI： 10.4049/jimmunol.166.1.531
Source DB: PubMed Journal: J Immunol ISSN： 0022-1767 Impact factor: 5.422