Literature DB >> 11123031

The genetics of rheumatoid arthritis: influences on susceptibility, severity, and treatment response.

S L Bridges1.   

Abstract

There has been an explosion of knowledge of genetic variations among different populations and the influence of genetics on complex diseases such as rheumatoid arthritis (RA). Although class II major histocompatibility complex (MHC) alleles are important contributors, there are likely multiple other genes that modulate the disease phenotype. Genetic markers may allow prediction of response to particular treatments. Given the recent approval of tumor necrosis factors (TNF) inhibitors and the large number of biologic agents currently undergoing clinical trials, pharmacogenetic markers may prove to be clinically useful.

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Year:  1999        PMID： 11123031     DOI： 10.1007/s11926-999-0014-4

Source DB:  PubMed          Journal:  Curr Rheumatol Rep        ISSN： 1523-3774            Impact factor:   4.592


  74 in total

1.  Allelic variants of human TCR BV17S1 defined by restriction fragment length polymorphism, single strand conformation polymorphism, and amplification refractory mutation system analyses.

Authors:  Y Li; G R Sun; Q Zheng; D H Yoo; N Bhardwaj; D N Posnett; M K Crow; S M Friedman
Journal:  Hum Immunol       Date:  1996-09-01       Impact factor: 2.850

2.  HLA-linked rheumatoid arthritis.

Authors:  S J Hasstedt; D O Clegg; L Ingles; R H Ward
Journal:  Am J Hum Genet       Date:  1994-10       Impact factor: 11.025

3.  DR3 and nonDR3 associated complement component C4A deficiency in systemic lupus erythematosus.

Authors:  A Kumar; P Kumar; P H Schur
Journal:  Clin Immunol Immunopathol       Date:  1991-07

4.  Patterns of radiological progression in early rheumatoid arthritis: results of an 8 year prospective study.

Authors:  M J Plant; P W Jones; J Saklatvala; W E Ollier; P T Dawes
Journal:  J Rheumatol       Date:  1998-03       Impact factor: 4.666

5.  Association of tumor necrosis factor microsatellite polymorphisms with HLA-DRB1*04-bearing haplotypes in rheumatoid arthritis patients.

Authors:  A H Hajeer; J Worthington; A J Silman; W E Ollier
Journal:  Arthritis Rheum       Date:  1996-07

6.  TNF Nco-I RFLP is not an independent risk factor in rheumatoid arthritis.

Authors:  D A Campbell; S Nelson; R Madhok; M Field; G Gallagher
Journal:  Eur J Immunogenet       Date:  1994-12

7.  Genetic variability in the tumor necrosis factor-lymphotoxin region influences susceptibility to rheumatoid arthritis.

Authors:  B Mulcahy; F Waldron-Lynch; M F McDermott; C Adams; C I Amos; D K Zhu; R H Ward; D O Clegg; F Shanahan; M G Molloy; F O'Gara
Journal:  Am J Hum Genet       Date:  1996-09       Impact factor: 11.025

8.  Etanercept therapy in rheumatoid arthritis. A randomized, controlled trial.

Authors:  L W Moreland; M H Schiff; S W Baumgartner; E A Tindall; R M Fleischmann; K J Bulpitt; A L Weaver; E C Keystone; D E Furst; P J Mease; E M Ruderman; D A Horwitz; D G Arkfeld; L Garrison; D J Burge; C M Blosch; M L Lange; N D McDonnell; M E Weinblatt
Journal:  Ann Intern Med       Date:  1999-03-16       Impact factor: 25.391

9.  Effects of a polymorphism in the human tumor necrosis factor alpha promoter on transcriptional activation.

Authors:  A G Wilson; J A Symons; T L McDowell; H O McDevitt; G W Duff
Journal:  Proc Natl Acad Sci U S A       Date:  1997-04-01       Impact factor: 11.205

10.  The effect of novel polymorphisms in the interleukin-6 (IL-6) gene on IL-6 transcription and plasma IL-6 levels, and an association with systemic-onset juvenile chronic arthritis.

Authors:  D Fishman; G Faulds; R Jeffery; V Mohamed-Ali; J S Yudkin; S Humphries; P Woo
Journal:  J Clin Invest       Date:  1998-10-01       Impact factor: 14.808
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  5 in total

1.  Multidrug resistance 1 (MDR1) 3435C>T gene polymorphism influences the clinical phenotype and methotrexate-induced adverse events in South Indian Tamil rheumatoid arthritis.

Authors:  Niveditha Muralidharan; Paul T Antony; Vikramraj K Jain; Christina Mary Mariaselvam; Vir Singh Negi
Journal:  Eur J Clin Pharmacol       Date:  2015-06-14       Impact factor: 2.953

2.  Opposing effects of the D70 mutation and the shared epitope in HLA-DR4 on disease activity and certain disease phenotypes in rheumatoid arthritis.

Authors:  N A Shadick; J E Heller; M E Weinblatt; N E Maher; J Cui; G Ginsburg; J Coblyn; R Anderson; D H Solomon; R Roubenoff; A Parker
Journal:  Ann Rheum Dis       Date:  2007-05-09       Impact factor: 19.103

Review 3.  Applying science in practice: the optimization of biological therapy in rheumatoid arthritis.

Authors:  Sofia Ramiro; Pedro Machado; Jasvinder A Singh; Robert B Landewé; José António P da Silva
Journal:  Arthritis Res Ther       Date:  2010-11-04       Impact factor: 5.156

4.  Crosslinks Between Human Leukocyte Antigen DRB1*01 and Human Leukocyte Antigen DRB1*13 Allelic Variants and Occurrence of Rheumatoid Arthritis in Patients From Federation of Bosnia and Herzegovina.

Authors:  Elma Fejzic; Amela Sahovic; Sanela Sisic; Andi Alijagic; Damir Suljevic
Journal:  Arch Rheumatol       Date:  2017-05-25       Impact factor: 1.472

5.  Gene polymorphisms and pharmacogenetics in rheumatoid arthritis.

Authors:  Ignacio Rego-Pérez; Mercedes Fernández-Moreno; Francisco J Blanco
Journal:  Curr Genomics       Date:  2008-09       Impact factor: 2.236
  5 in total

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