Genetic predictors of plasma lipid response to diet intervention.

There is a growing interest in determining the genetic predictors of plasma lipid response to diet intervention. Several candidate gene loci, namely, apolipoprotein (APO) A1, APOA4, APOC3, APOB, APOE, CETP, LPL, and FABP2, have been shown to explain a significant, but still rather small, proportion of the interindividual variability in dietary response. Other gene loci code for products that play a relevant role in lipoprotein metabolism and are prime candidates for future studies (ie, CYP7). Future progress in this complex area will come from experiments carried out using animal models and from carefully controlled dietary protocols in humans.