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Literature DB >> 11122521

The fungal metabolite culmorin and related compounds.

Abstract

This paper reviews the toxicology of culmorins, a family of compounds found in grains contaminated by Fusarium graminearum and related fungi. We include the results of an Ames test and studies based on Quantitative Structure-Activity Relationships. Culmorin has low toxicity in several in vitro assays and in one study in swine and is Ames test negative. Culmorin is moderately antifungal. QSAR analysis suggested that the plant compound longifolene was similar. Longifolene is a GRAS compound used in cosmetics and is also moderately antifungal.

Entities: Chemical Disease Species

Mesh：

Substances：

Year: 1999 PMID： 11122521 DOI： 10.1002/1522-7189(199911/12)7:6<305::aid-nt72>3.0.co;2-g

Source DB: PubMed Journal: Nat Toxins ISSN： 1056-9014

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Cited

7 in total

1. CLM1 of Fusarium graminearum encodes a longiborneol synthase required for culmorin production.

Authors: S P McCormick; N J Alexander; L J Harris
Journal: Appl Environ Microbiol Date: 2009-10-30 Impact factor: 4.792

2. A multi-year survey of mycotoxins and ergosterol in Canadian oats.

Authors: Sheryl A Tittlemier; Richard Blagden; Jason Chan; Mike Roscoe; Kerri Pleskach
Journal: Mycotoxin Res Date: 2019-09-11 Impact factor: 3.833

3. The occurrence of culmorin and hydroxy-culmorins in cereals.

Authors: M Ghebremeskel; W Langseth
Journal: Mycopathologia Date: 2001 Impact factor: 2.574

4. Structure-based virtual screening of hypothetical inhibitors of the enzyme longiborneol synthase-a potential target to reduce Fusarium head blight disease.

Authors: E Bresso; V Leroux; M Urban; K E Hammond-Kosack; B Maigret; N F Martins
Journal: J Mol Model Date: 2016-06-21 Impact factor: 1.810

The fungal metabolite culmorin and related compounds.

1. CLM1 of Fusarium graminearum encodes a longiborneol synthase required for culmorin production.

2. A multi-year survey of mycotoxins and ergosterol in Canadian oats.

3. The occurrence of culmorin and hydroxy-culmorins in cereals.

4. Structure-based virtual screening of hypothetical inhibitors of the enzyme longiborneol synthase-a potential target to reduce Fusarium head blight disease.

5. Multi-mycotoxin screening reveals the occurrence of 139 different secondary metabolites in feed and feed ingredients.

6. Effects of Citric and Lactic Acid on the Reduction of Deoxynivalenol and Its Derivatives in Feeds.

Review 7. Comprehensive Description of Fusarium graminearum Pigments and Related Compounds.