Literature DB >> 11122

[Effect of liver damage by thioacetamide on microsomal aromatization of testosterone in rats (author's transl)].

V L Del Pino, H M Bolt.   

Abstract

Rat liver microsomes, NADPH-regenerating system, and 1beta, 2beta-3H-testosterone have been incubated in vitro. The loss of tritium from the steroid, associated with aromatization of testosterone, was linear with time for 20 min and required NADPH. Pre-treatment of the rats with thioacetamide raised the liberation of tritium from 1beta, 2beta-3H-testosterone. The results suggest that liver damage by thioacetamide in rats may give rise to increased aromatization of testosterone.

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Year:  1976        PMID： 11122     DOI： 10.1007/BF01937431

Source DB:  PubMed          Journal:  Experientia        ISSN： 0014-4754


  3 in total

1.  Studies on the mechanism of estrogen biosynthesis. VI. The stereochemistry of hydrogen elimination at C-2 during aromatization.

Authors:  H J Brodie; K J Kripalani; G Possanza
Journal:  J Am Chem Soc       Date:  1969-02-26       Impact factor: 15.419

2.  [Inactivation of estradiol by oxidation following liver damage in rats and in patients with liver diseases].

Authors:  M Wenzel; K U Blum; E Kraas
Journal:  Z Klin Chem Klin Biochem       Date:  1968-06

3.  [The thioacetamide-poisoned rat as an animal experimental model for endocrinological studies of estrogen metabolism in chronic liver injury)].

Authors:  V Lopez del Pino; H M Bolt
Journal:  Endokrinologie       Date:  1975-12
  3 in total

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