Literature DB >> 11121618

Isosterism among analogues of torasemide: conformational, electronic and lipophilic properties.

J Wouters1, C Michaux, F Durant, J M Dogné, J Delarge, B Masereel.   

Abstract

The structures, electronic (charges, molecular electrostatic potential, molecular orbitals) and lipophilic properties of three isostere analogues of torasemide were determined and the influence of the replacement of the sulfonyl urea group on the conformation and electronic properties of the molecules is discussed. Lipophilicity of the compounds seems to be the most discriminating property along the series and affects their pharmacological activities.

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Year:  2000        PMID： 11121618     DOI： 10.1016/s0223-5234(00)01174-0

Source DB:  PubMed          Journal:  Eur J Med Chem        ISSN： 0223-5234            Impact factor:   6.514


  3 in total

1.  Modeling of Anticancer Sulfonamide Derivatives Lipophilicity by Chemometric and Quantitative Structure-Retention Relationships Approaches.

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Journal:  Molecules       Date:  2022-06-21       Impact factor: 4.927

Review 2.  Recent advances in urea- and thiourea-containing compounds: focus on innovative approaches in medicinal chemistry and organic synthesis.

Authors:  Riccardo Ronchetti; Giada Moroni; Andrea Carotti; Antimo Gioiello; Emidio Camaioni
Journal:  RSC Med Chem       Date:  2021-05-13

3.  Syntheses of Novel 4-Substituted N-(5-amino-1H-1,2,4-triazol-3-yl)pyridine-3-sulfonamide Derivatives with Potential Antifungal Activity.

Authors:  Krzysztof Szafrański; Jarosław Sławiński; Anna Kędzia; Ewa Kwapisz
Journal:  Molecules       Date:  2017-11-07       Impact factor: 4.411
  3 in total

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