Literature DB >> 11121587

Alternative splicing of the human PTEN/MMAC1/TEP1 gene.

R M Sharrard1, N J Maitland.   

Abstract

The human tumour suppressor gene PTEN/MMAC1/TEP1 encodes a lipid and protein phosphatase. Using RT-PCR, alternatively spliced forms of PTEN mRNA, encoding full-length PTEN and two forms of the protein truncated at the C-terminal end, were detected in normal human tissue. Cultured tumour and non-tumour cell lines show similar splicing patterns.

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Year:  2000        PMID： 11121587     DOI： 10.1016/s0167-4781(00)00210-4

Source DB:  PubMed          Journal:  Biochim Biophys Acta        ISSN： 0006-3002


  10 in total

1.  Distinct expression profiles for PTEN transcript and its splice variants in Cowden syndrome and Bannayan-Riley-Ruvalcaba syndrome.

Authors:  Marta S Sarquis; Shipra Agrawal; Lei Shen; Robert Pilarski; Xiao-Ping Zhou; Charis Eng
Journal:  Am J Hum Genet       Date:  2006-05-22       Impact factor: 11.025

Review 2.  PTEN proteoforms in biology and disease.

Authors:  Prerna Malaney; Vladimir N Uversky; Vrushank Davé
Journal:  Cell Mol Life Sci       Date:  2017-03-13       Impact factor: 9.261

3.  Ras promotes growth by alternative splicing-mediated inactivation of the KLF6 tumor suppressor in hepatocellular carcinoma.

Authors:  Steven Yea; Goutham Narla; Xiao Zhao; Rakhi Garg; Sigal Tal-Kremer; Eldad Hod; Augusto Villanueva; Johnny Loke; Mirko Tarocchi; Kunihara Akita; Senji Shirasawa; Takehiko Sasazuki; John A Martignetti; Josep M Llovet; Scott L Friedman
Journal:  Gastroenterology       Date:  2008-02-13       Impact factor: 22.682

4.  An intronic polymorphic deletion in the PTEN gene: implications for molecular diagnostic testing.

Authors:  S Sandell; R J L Schuit; D J Bunyan
Journal:  Br J Cancer       Date:  2013-01-08       Impact factor: 7.640

5.  PTEN transcript variants caused by illegitimate splicing in "aged" blood samples and EBV-transformed cell lines.

Authors:  Yunying Liu; Priyangi Malaviarachchi; Marjorie Beggs; Peter D Emanuel
Journal:  Hum Genet       Date:  2010-09-14       Impact factor: 4.132

Review 6.  The Complex Landscape of PTEN mRNA Regulation.

Authors:  Erin Sellars; Martino Gabra; Leonardo Salmena
Journal:  Cold Spring Harb Perspect Med       Date:  2020-06-01       Impact factor: 5.159

7.  Coiled-coil domain containing 68 (CCDC68) demonstrates a tumor-suppressive role in pancreatic ductal adenocarcinoma.

Authors:  N Radulovich; L Leung; E Ibrahimov; R Navab; S Sakashita; C-Q Zhu; E Kaufman; W W Lockwood; K L Thu; Y Fedyshyn; J Moffat; W L Lam; M-S Tsao
Journal:  Oncogene       Date:  2014-11-10       Impact factor: 9.867

8.  In renal cell carcinoma the PTEN splice variant PTEN-Δ shows similar function as the tumor suppressor PTEN itself.

Authors:  Ines Breuksch; Jonas Welter; Heide-Katharina Bauer; Thorsten Enklaar; Sebastian Frees; Joachim W Thüroff; Annette Hasenburg; Dirk Prawitt; Walburgis Brenner
Journal:  Cell Commun Signal       Date:  2018-06-28       Impact factor: 5.712

9.  Identification of a Cowden syndrome patient with a novel PTEN mutation and establishment of patient-derived induced pluripotent stem cells.

Authors:  Fumitaka Obayashi; Atsuko Hamada; Sachiko Yamasaki; Taku Kanda; Shigeaki Toratani; Tetsuji Okamoto
Journal:  In Vitro Cell Dev Biol Anim       Date:  2022-01-03       Impact factor: 2.416

10.  Alternative Splicing of MoPTEN Is Important for Growth and Pathogenesis in Magnaporthe oryzae.

Authors:  Shaowei Wang; Hao Liang; Yi Wei; Penghui Zhang; Yuejia Dang; Guihua Li; Shi-Hong Zhang
Journal:  Front Microbiol       Date:  2021-07-16       Impact factor: 5.640
  10 in total

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