Literature DB >> 11121561

The transmission dynamics of the aetiological agent of scrapie in a sheep flock.

T J Hagenaars1, C A Donnelly, N M Ferguson, R M Anderson.   

Abstract

We formulate and investigate the properties of a model framework to mimic the transmission dynamics of the aetiological agent of scrapie in a sheep flock. We derive expressions for summary parameters that characterize transmission scenarios, notably the basic reproduction number R(0) and the mean generation time T(g). The timescale of epidemic outbreaks is expressed in terms of R(0) and cumulants of the generation time distribution. We discuss the relative contributions to the overall rate of transmission of horizontal and vertical routes during invasion and in endemicity. Simplified models are used to obtain analytical insight into the characteristics of the endemic state.

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Year:  2000        PMID： 11121561     DOI： 10.1016/s0025-5564(00)00048-1

Source DB:  PubMed          Journal:  Math Biosci        ISSN： 0025-5564            Impact factor:   2.144


  9 in total

1.  Epidemiological analysis of data for scrapie in Great Britain.

Authors:  T J Hagenaars; C A Donnelly; N M Ferguson
Journal:  Epidemiol Infect       Date:  2006-04       Impact factor: 2.451

2.  Surveillance and simulation of bovine spongiform encephalopathy and scrapie in small ruminants in Switzerland.

Authors:  Chantal Häusermann; Heinzpeter Schwermer; Anna Oevermann; Alice Nentwig; Andreas Zurbriggen; Dagmar Heim; Torsten Seuberlich
Journal:  BMC Vet Res       Date:  2010-04-18       Impact factor: 2.741

Review 3.  The role of mathematical modelling in understanding the epidemiology and control of sheep transmissible spongiform encephalopathies: a review.

Authors:  Simon Gubbins; Suzanne Touzeau; Thomas J Hagenaars
Journal:  Vet Res       Date:  2010-02-23       Impact factor: 3.683

4.  Scrapie prevalence in sheep of susceptible genotype is declining in a population subject to breeding for resistance.

Authors:  Thomas J Hagenaars; Marielle B Melchior; Alex Bossers; Aart Davidse; Bas Engel; Fred G van Zijderveld
Journal:  BMC Vet Res       Date:  2010-05-14       Impact factor: 2.741

5.  Breeding with resistant rams leads to rapid control of classical scrapie in affected sheep flocks.

Authors:  Gonnie Nodelijk; Herman J W van Roermund; Lucien J M van Keulen; Bas Engel; Piet Vellema; Thomas J Hagenaars
Journal:  Vet Res       Date:  2011-01-11       Impact factor: 3.683

6.  Use of a preclinical test in the control of classical scrapie.

Authors:  L A Boden; F Houston; H R Fryer; R R Kao
Journal:  J Gen Virol       Date:  2010-06-23       Impact factor: 3.891

7.  An economic evaluation of preclinical testing strategies compared to the compulsory scrapie flock scheme in the control of classical scrapie.

Authors:  Lisa Boden; Ian Handel; Neil Hawkins; Fiona Houston; Helen Fryer; Rowland Kao
Journal:  PLoS One       Date:  2012-03-07       Impact factor: 3.240

8.  Investigation of a Simple Model for Within-Flock Transmission of Scrapie.

Authors:  Thomas J Hagenaars; Jack J Windig
Journal:  PLoS One       Date:  2015-10-01       Impact factor: 3.240

9.  Implications of conflicting associations of the prion protein (PrP) gene with scrapie susceptibility and fitness on the persistence of scrapie.

Authors:  Andrea Doeschl-Wilson; Rami Sawalha; Simon Gubbins; Beatriz Villanueva
Journal:  PLoS One       Date:  2009-11-24       Impact factor: 3.240
  9 in total

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