Literature DB >> 11121537

Expression of CD40 in the brain of Alzheimer's disease and other neurological diseases.

T Togo1, H Akiyama, H Kondo, K Ikeda, M Kato, E Iseki, K Kosaka.   

Abstract

We have investigated immunohistochemically the expression of CD40 in post-mortem human brain tissues. In control brain, the blood vessels were stained weakly for CD40. Vascular expression of CD40 was enhanced in the lesions of Alzheimer's disease and some other neurological diseases. In such diseases, reactive microglia were also positive for CD40. The results of this study suggest that CD40 expression by microglia is up-regulated upon a variety of brain insults and is not limited to lesions with amyloid beta-protein deposits.

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Year:  2000        PMID： 11121537     DOI： 10.1016/s0006-8993(00)02984-x

Source DB:  PubMed          Journal:  Brain Res        ISSN： 0006-8993            Impact factor:   3.252


  41 in total

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4.  Critical role of microglial CD40 in the maintenance of mechanical hypersensitivity in a murine model of neuropathic pain.

Authors:  Ling Cao; Christopher D Palmer; Jennifer T Malon; Joyce A De Leo
Journal:  Eur J Immunol       Date:  2009-12       Impact factor: 5.532

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Review 7.  Mechanisms of anti-inflammatory and neuroprotective actions of PPAR-gamma agonists.

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8.  SOLUBLE CD40 LIGAND IN DEMENTIA.

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Review 9.  Can peripheral leukocytes be used as Alzheimer's disease biomarkers?

Authors:  Kavon Rezai-Zadeh; David Gate; Christine A Szekely; Terrence Town
Journal:  Expert Rev Neurother       Date:  2009-11       Impact factor: 4.618

10.  Pro-Resolving Lipid Mediators Improve Neuronal Survival and Increase Aβ42 Phagocytosis.

Authors:  Mingqin Zhu; Xiuzhe Wang; Erik Hjorth; Romain A Colas; Lisa Schroeder; Ann-Charlotte Granholm; Charles N Serhan; Marianne Schultzberg
Journal:  Mol Neurobiol       Date:  2015-12-09       Impact factor: 5.590
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