Literature DB >> 11121000

Therapeutic efficacy of Poly(DL-lactide-Co-Glycolide)-encapsulated antitubercular drugs against Mycobacterium tuberculosis infection induced in mice.

M Dutt1, G K Khuller.   

Abstract

Poly(DL-lactide-co-glycolide) (PLG) microparticles were developed as carriers for isoniazid and rifampin in order to improve compliance of tuberculous chemotherapy. Antitubercular drugs encapsulated in PLG polymers and injected in a single dose subcutaneously resulted in a sustained release (up to 6 weeks) of drugs in various organs of mice. Further, Mycobacterium tuberculosis H(37)Rv-infected animals given a single shot of chemotherapy in PLG microparticles exhibited a better or equivalent clearance of CFU in various organs compared to those given a daily administration of free drugs.

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Year:  2001        PMID： 11121000      PMCID： PMC90295          DOI： 10.1128/AAC.45.1.363-366.2001

Source DB:  PubMed          Journal:  Antimicrob Agents Chemother        ISSN： 0066-4804            Impact factor:   5.191


  10 in total

1.  Biodegradation and biocompatibility of PLA and PLGA microspheres.

Authors: 
Journal:  Adv Drug Deliv Rev       Date:  1997-10-13       Impact factor: 15.470

2.  Efficacy of microencapsulated rifampin in Mycobacterium tuberculosis-infected mice.

Authors:  D C Quenelle; J K Staas; G A Winchester; E L Barrow; W W Barrow
Journal:  Antimicrob Agents Chemother       Date:  1999-05       Impact factor: 5.191

3.  Sustained release of isoniazid in vivo from a single implant of a biodegradable polymer.

Authors:  P R Gangadharam; D R Ashtekar; D C Farhi; D L Wise
Journal:  Tubercle       Date:  1991-06

4.  Large porous particles for pulmonary drug delivery.

Authors:  D A Edwards; J Hanes; G Caponetti; J Hrkach; A Ben-Jebria; M L Eskew; J Mintzes; D Deaver; N Lotan; R Langer
Journal:  Science       Date:  1997-06-20       Impact factor: 47.728

5.  Maintenance of therapeutically active levels of isoniazid for prolonged periods in rabbits after a single implant of biodegradable polymer.

Authors:  S Kailasam; D Daneluzzi; P R Gangadharam
Journal:  Tuber Lung Dis       Date:  1994-10

6.  Fluorometric determination of isonicotinic acid hydrazide in serum.

Authors:  E M Scott; R C Wright
Journal:  J Lab Clin Med       Date:  1967-08

7.  Immunogenicity of ribonucleic acid-protein fraction of Mycobacterium tuberculosis encapsulated in liposomes.

Authors:  P Pancholi; V K Vinayak; G K Khuller
Journal:  J Med Microbiol       Date:  1989-06       Impact factor: 2.472

8.  Experimental chemotherapy of tuberculosis using single dose treatment with isoniazid in biodegradable polymers.

Authors:  P R Gangadharam; S Kailasam; S Srinivasan; D L Wise
Journal:  J Antimicrob Chemother       Date:  1994-02       Impact factor: 5.790

9.  Therapeutic efficacy of liposome-entrapped rifampin against Mycobacterium avium complex infection induced in mice.

Authors:  H Saito; H Tomioka
Journal:  Antimicrob Agents Chemother       Date:  1989-04       Impact factor: 5.191

10.  Use of microsphere technology for targeted delivery of rifampin to Mycobacterium tuberculosis-infected macrophages.

Authors:  E L Barrow; G A Winchester; J K Staas; D C Quenelle; W W Barrow
Journal:  Antimicrob Agents Chemother       Date:  1998-10       Impact factor: 5.191
  10 in total
  2 in total

1.  Soft particle analysis of electrokinetics of biological cells and their model systems.

Authors:  Kimiko Makino; Hiroyuki Ohshima
Journal:  Sci Technol Adv Mater       Date:  2011-04-26       Impact factor: 8.090

2.  Chemotherapeutic potential of orally administered poly(lactide-co-glycolide) microparticles containing isoniazid, rifampin, and pyrazinamide against experimental tuberculosis.

Authors:  Qurrat Ul-Ain; Sadhna Sharma; G K Khuller
Journal:  Antimicrob Agents Chemother       Date:  2003-09       Impact factor: 5.191
  2 in total

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