Literature DB >> 11120997

In vitro pharmacodynamic studies of activities of ketolides HMR 3647 (Telithromycin) and HMR 3004 against extracellular or intracellular Helicobacter pylori.

I Gustafsson1, L Engstrand, O Cars.   

Abstract

The pharmacodynamic properties of the ketolides HMR 3647 (telithromycin) and HMR 3004 were studied against Helicobacter pylori. Both ketolides showed a pronounced concentration-dependent killing, a significant postantibiotic effect, a long postantibiotic sub-MIC effect, and a reduction of intracellular H. pylori.

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Year:  2001        PMID： 11120997      PMCID： PMC90292          DOI： 10.1128/AAC.45.1.353-355.2001

Source DB:  PubMed          Journal:  Antimicrob Agents Chemother        ISSN： 0066-4804            Impact factor:   5.191


  12 in total

1.  Interactions between HMR 3647, a new ketolide, and human polymorphonuclear neutrophils.

Authors:  D Vazifeh; A Preira; A Bryskier; M T Labro
Journal:  Antimicrob Agents Chemother       Date:  1998-08       Impact factor: 5.191

2.  Bacterium-host interactions monitored by time-lapse photography.

Authors:  C Löfman; R Rigo; M Block; K Hultén; H Enroth; L Engstrand
Journal:  Nat Med       Date:  1997-08       Impact factor: 53.440

3.  In vitro aging of Helicobacter pylori: changes in morphology, intracellular composition and surface properties.

Authors:  H Enroth; K Wreiber; R Rigo; D Risberg; A Uribe; L Engstrand
Journal:  Helicobacter       Date:  1999-03       Impact factor: 5.753

4.  Adherence and internalization of Helicobacter pylori by HEp-2 cells.

Authors:  D G Evans; D J Evans; D Y Graham
Journal:  Gastroenterology       Date:  1992-05       Impact factor: 22.682

Review 5.  Pharmacokinetic/pharmacodynamic parameters: rationale for antibacterial dosing of mice and men.

Authors:  W A Craig
Journal:  Clin Infect Dis       Date:  1998-01       Impact factor: 9.079

6.  Pharmacodynamic properties of HMR 3647, a novel ketolide, on respiratory pathogens, enterococci and Bacteroides fragilis demonstrated by studies of time-kill kinetics and postantibiotic effect.

Authors:  F J Boswell; J M Andrews; R Wise
Journal:  J Antimicrob Chemother       Date:  1998-02       Impact factor: 5.790

7.  New pharmacokinetic in vitro model for studies of antibiotic activity against intracellular microorganisms.

Authors:  K Hultén; R Rigo; I Gustafsson; L Engstrand
Journal:  Antimicrob Agents Chemother       Date:  1996-12       Impact factor: 5.191

8.  Combination treatment with ranitidine is highly efficient against Helicobacter pylori despite negative impact of macrolide resistance.

Authors:  K Hultén; B Jaup; B Stenquist; L Engstrand
Journal:  Helicobacter       Date:  1997-12       Impact factor: 5.753

9.  Cellular accumulation of the new ketolide RU 64004 by human neutrophils: comparison with that of azithromycin and roxithromycin.

Authors:  D Vazifeh; H Abdelghaffar; M T Labro
Journal:  Antimicrob Agents Chemother       Date:  1997-10       Impact factor: 5.191

10.  Postantibiotic effects and postantibiotic sub-MIC effects of roxithromycin, clarithromycin, and azithromycin on respiratory tract pathogens.

Authors:  I Odenholt-Tornqvist; E Löwdin; O Cars
Journal:  Antimicrob Agents Chemother       Date:  1995-01       Impact factor: 5.191
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  4 in total

1.  Sulforaphane inhibits extracellular, intracellular, and antibiotic-resistant strains of Helicobacter pylori and prevents benzo[a]pyrene-induced stomach tumors.

Authors:  Jed W Fahey; Xavier Haristoy; Patrick M Dolan; Thomas W Kensler; Isabelle Scholtus; Katherine K Stephenson; Paul Talalay; Alain Lozniewski
Journal:  Proc Natl Acad Sci U S A       Date:  2002-05-28       Impact factor: 11.205

Review 2.  The ketolides: a critical review.

Authors:  George G Zhanel; Michael Walters; Ayman Noreddin; Lavern M Vercaigne; Aleksandra Wierzbowski; John M Embil; Alfred S Gin; Stephen Douthwaite; Daryl J Hoban
Journal:  Drugs       Date:  2002       Impact factor: 9.546

Review 3.  Antibiotics for treatment of resistant gram-positive coccal infections.

Authors:  Hossam Al-Tatari; Nahed Abdel-Haq; Pimpanada Chearskul; Basim Asmar
Journal:  Indian J Pediatr       Date:  2006-04       Impact factor: 5.319

4.  A long-distance rRNA base pair impacts the ability of macrolide antibiotics to kill bacteria.

Authors:  Maxim S Svetlov; Sophie Cohen; Nada Alsuhebany; Nora Vázquez-Laslop; Alexander S Mankin
Journal:  Proc Natl Acad Sci U S A       Date:  2020-01-13       Impact factor: 11.205
  4 in total

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