Literature DB >> 11120868

Tyrosinase family proteins are antigens specific to Vogt-Koyanagi-Harada disease.

K Yamaki1, K Gocho, K Hayakawa, I Kondo, S Sakuragi.   

Abstract

Vogt-Koyanagi-Harada (VKH) disease (and sympathetic ophthalmia) is an ocular inflammatory disease that is considered to be a cell-mediated autoimmune disease against melanocytes. The purpose of this study was to determine the Ags specific to VKH disease and to develop an animal model of VKH disease. We found that exposure of lymphocytes from patients with VKH disease to peptides (30-mer) derived from the tyrosinase family proteins led to significant proliferation of the lymphocytes. Immunization of these peptides into pigmented rats induced ocular and extraocular changes that highly resembled human VKH disease, and we suggest that an experimental VKH disease was induced in these rats. We conclude that VKH disease is an autoimmune disease against the tyrosinase family proteins.

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Year:  2000        PMID： 11120868     DOI： 10.4049/jimmunol.165.12.7323

Source DB:  PubMed          Journal:  J Immunol        ISSN： 0022-1767            Impact factor:   5.422


  42 in total

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2.  Indocyanine green angiography-guided management of Vogt-Koyanagi-Harada disease: differentiation between choroidal scars and active lesions.

Authors:  Pascal B Knecht; Alessandro Mantovani; Carl P Herbort
Journal:  Int Ophthalmol       Date:  2013-01-01       Impact factor: 2.031

3.  Posterior segment recurrences in Vogt-Koyanagi-Harada disease.

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Journal:  Int Ophthalmol       Date:  2007-09-26       Impact factor: 2.031

4.  Trabecular meshwork depigmentation in Vogt-Koyanagi-Harada disease.

Authors:  Kazuomi Mizuuchi; Nobuyoshi Kitaichi; Kenichi Namba; Yukihiro Horie; Susumu Ishida; Shigeaki Ohno
Journal:  Jpn J Ophthalmol       Date:  2013-01-29       Impact factor: 2.447

5.  Initial-onset acute uveitis associated with Vogt-Koyanagi-Harada disease presenting with unilateral exudative retinal detachment despite bilateral choroidal involvement.

Authors:  Abdulrahman F AlBloushi; Carl P Herbort; Ahmed M Abu El-Asrar
Journal:  Int Ophthalmol       Date:  2021-08-03       Impact factor: 2.031

6.  Frequent immune response to a melanocyte specific protein KU-MEL-1 in patients with Vogt-Koyanagi-Harada disease.

Authors:  S Otani; T Sakurai; K Yamamoto; T Fujita; Y Matsuzaki; Y Goto; Y Ando; S Suzuki; M Usui; M Takeuchi; Y Kawakami
Journal:  Br J Ophthalmol       Date:  2006-02-15       Impact factor: 4.638

7.  A functional variant of pre-miRNA-196a2 confers risk for Behcet's disease but not for Vogt-Koyanagi-Harada syndrome or AAU in ankylosing spondylitis.

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Journal:  Hum Genet       Date:  2013-08-09       Impact factor: 4.132

8.  Uveodermatologic syndrome concurrent with keratoconjunctivitis sicca in a miniature poodle dog.

Authors:  Min-Hee Kang; Chae-Young Lim; Hee-Myung Park
Journal:  Can Vet J       Date:  2014-06       Impact factor: 1.008

9.  Evaluation of PTPN22 polymorphisms and Vogt-Koyanagi-Harada disease in Japanese patients.

Authors:  Yukihiro Horie; Nobuyoshi Kitaichi; Yoshihiko Katsuyama; Kazuhiko Yoshida; Toshie Miura; Masao Ota; Yuri Asukata; Hidetoshi Inoko; Nobuhisa Mizuki; Susumu Ishida; Shigeaki Ohno
Journal:  Mol Vis       Date:  2009-06-03       Impact factor: 2.367

10.  PDCD1 genes may protect against extraocular manifestations in Chinese Han patients with Vogt-Koyanagi-Harada syndrome.

Authors:  Qianli Meng; Xiaoli Liu; Peizeng Yang; Shengping Hou; Liping Du; Hongyan Zhou; Aize Kijlstra
Journal:  Mol Vis       Date:  2009-02-20       Impact factor: 2.367
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