OBJECTIVE: Syndecan 1 is a cell surface heparan sulfate proteoglycan that binds growth factors and antithrombin III. The objective of this study was to examine whether placental expression of syndecan 1 in preeclampsia differs from that in normal pregnancy and whether gestational age and fetal growth affect syndecan 1 expression. STUDY DESIGN: An immunohistochemical analysis of 30 placentas of women with severe preeclampsia and 15 placentas of women without preeclampsia was performed with the monoclonal anti-syndecan 1 antibody B-B4. RESULTS: In 47% of preeclamptic placentas the immunoreactivity with antibody B-B4 was faint or absent, whereas 93% of the normal placentas exhibited strong immunoreactivity. The reduction in placental expression of syndecan 1 in preeclampsia was not associated with gestational age or impaired fetal growth. CONCLUSION: The expression of syndecan 1 on the chorionic villi is reduced in preeclampsia irrespective of gestational age or fetal growth.
OBJECTIVE:Syndecan 1 is a cell surface heparan sulfate proteoglycan that binds growth factors and antithrombin III. The objective of this study was to examine whether placental expression of syndecan 1 in preeclampsia differs from that in normal pregnancy and whether gestational age and fetal growth affect syndecan 1 expression. STUDY DESIGN: An immunohistochemical analysis of 30 placentas of women with severe preeclampsia and 15 placentas of women without preeclampsia was performed with the monoclonal anti-syndecan 1 antibody B-B4. RESULTS: In 47% of preeclamptic placentas the immunoreactivity with antibody B-B4 was faint or absent, whereas 93% of the normal placentas exhibited strong immunoreactivity. The reduction in placental expression of syndecan 1 in preeclampsia was not associated with gestational age or impaired fetal growth. CONCLUSION: The expression of syndecan 1 on the chorionic villi is reduced in preeclampsia irrespective of gestational age or fetal growth.
Authors: Szilvia Szabo; Yi Xu; Roberto Romero; Tibor Fule; Katalin Karaszi; Gaurav Bhatti; Tibor Varkonyi; Ildiko Varkonyi; Tibor Krenacs; Zhong Dong; Adi L Tarca; Tinnakorn Chaiworapongsa; Sonia S Hassan; Zoltan Papp; Ilona Kovalszky; Nandor Gabor Than Journal: Virchows Arch Date: 2013-06-27 Impact factor: 4.064
Authors: Robin E Gandley; Andrew Althouse; Arundhathi Jeyabalan; Julia M Bregand-White; Stacy McGonigal; Ashley C Myerski; Marcia Gallaher; Robert W Powers; Carl A Hubel Journal: PLoS One Date: 2016-06-14 Impact factor: 3.240