Literature DB >> 11119827

Non-FcR-binding, humanized anti-CD3 antibody Hu291 induces apoptosis of human T cells more effectively than OKT3 and is immunosuppressive in vivo.

P A Carpenter1, J Y Tso, O W Press, X Yu, C Anasetti.   

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Year:  2000        PMID： 11119827     DOI： 10.1016/s0041-1345(00)01343-9

Source DB:  PubMed          Journal:  Transplant Proc        ISSN： 0041-1345            Impact factor:   1.066


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  3 in total

1.  TCR stimulation with modified anti-CD3 mAb expands CD8+ T cell population and induces CD8+CD25+ Tregs.

Authors:  Brygida Bisikirska; John Colgan; Jeremy Luban; Jeffrey A Bluestone; Kevan C Herold
Journal:  J Clin Invest       Date:  2005-09-15       Impact factor: 14.808

2.  Treatment of patients with new onset Type 1 diabetes with a single course of anti-CD3 mAb Teplizumab preserves insulin production for up to 5 years.

Authors:  Kevan C Herold; Stephen Gitelman; Carla Greenbaum; Jennifer Puck; William Hagopian; Peter Gottlieb; Peter Sayre; Peter Bianchine; Emelita Wong; Vicki Seyfert-Margolis; Kasia Bourcier; Jeffrey A Bluestone
Journal:  Clin Immunol       Date:  2009-05-14       Impact factor: 3.969

3.  Activation of human T cells by FcR nonbinding anti-CD3 mAb, hOKT3gamma1(Ala-Ala).

Authors:  Kevan C Herold; Joshua B Burton; Fleur Francois; Ena Poumian-Ruiz; Mariela Glandt; Jeffrey A Bluestone
Journal:  J Clin Invest       Date:  2003-02       Impact factor: 14.808
  3 in total

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