Literature DB >> 11119559

Severe schistosomiasis in the absence of interleukin-4 (IL-4) is IL-12 independent.

E A Patton1, L R Brunet, A C La Flamme, J Pedras-Vasconcelos, M Kopf, E J Pearce.   

Abstract

An interleukin-4 (IL-4)-dependent Th2 response allows wild-type mice to survive infection with the parasite Schistosoma mansoni. In the absence of IL-4, infected mice mount a Th1-like proinflammatory response, develop severe disease, and succumb. Neither the Th1 response nor morbidity is IL-12 dependent in this system.

Entities:  

Mesh：

Substances：

Year:  2001        PMID： 11119559      PMCID： PMC97925          DOI： 10.1128/IAI.69.1.589-592.2001

Source DB:  PubMed          Journal:  Infect Immun        ISSN： 0019-9567            Impact factor:   3.441


  21 in total

1.  Studies with double cytokine-deficient mice reveal that highly polarized Th1- and Th2-type cytokine and antibody responses contribute equally to vaccine-induced immunity to Schistosoma mansoni.

Authors:  K F Hoffmann; S L James; A W Cheever; T A Wynn
Journal:  J Immunol       Date:  1999-07-15       Impact factor: 5.422

2.  Schistosoma mansoni eggs induce antigen-responsive CD44-hi T helper 2 cells and IL-4-secreting CD44-lo cells. Potential for T helper 2 subset differentiation is evident at the precursor level.

Authors:  A T Vella; M D Hulsebosch; E J Pearce
Journal:  J Immunol       Date:  1992-09-01       Impact factor: 5.422

3.  Schistosomal egg antigen-responsive CD8 T-cell population in Schistosoma mansoni-infected BALB/c mice.

Authors:  V Pancré; M Delacre; J Herno; C Auriault
Journal:  Immunology       Date:  1999-12       Impact factor: 7.397

4.  The infection of laboratory hosts with cercariae of Schistosoma mansoni and the recovery of the adult worms.

Authors:  S R Smithers; R J Terry
Journal:  Parasitology       Date:  1965-11       Impact factor: 3.234

5.  Analysis of nitrate, nitrite, and [15N]nitrate in biological fluids.

Authors:  L C Green; D A Wagner; J Glogowski; P L Skipper; J S Wishnok; S R Tannenbaum
Journal:  Anal Biochem       Date:  1982-10       Impact factor: 3.365

6.  An IL-13 inhibitor blocks the development of hepatic fibrosis during a T-helper type 2-dominated inflammatory response.

Authors:  M G Chiaramonte; D D Donaldson; A W Cheever; T A Wynn
Journal:  J Clin Invest       Date:  1999-09       Impact factor: 14.808

7.  Schistosome-infected IL-4 receptor knockout (KO) mice, in contrast to IL-4 KO mice, fail to develop granulomatous pathology while maintaining the same lymphokine expression profile.

Authors:  D Jankovic; M C Kullberg; N Noben-Trauth; P Caspar; J M Ward; A W Cheever; W E Paul; A Sher
Journal:  J Immunol       Date:  1999-07-01       Impact factor: 5.422

8.  IL-12 is not required for induction of type 1 cytokine responses in viral infections.

Authors:  A Oxenius; U Karrer; R M Zinkernagel; H Hengartner
Journal:  J Immunol       Date:  1999-01-15       Impact factor: 5.422

Review 9.  Wasting in cancer.

Authors:  M J Tisdale
Journal:  J Nutr       Date:  1999-01       Impact factor: 4.798

10.  Delayed hypersensitivity-type granuloma formation and dermal reaction induced and elicited by a soluble factor isolated from Schistosoma mansoni eggs.

Authors:  D L Boros; K S Warren
Journal:  J Exp Med       Date:  1970-09-01       Impact factor: 14.307
View more
  7 in total

1.  Role of CTLA-4, IL-18 and IL-10 on the Induction of Low Dose Oral Tolerance.

Authors:  Kathleen Siobhan Barone; Rachael Burns; Stephanie Horton; Armando Retana; Lindsey Jackson Meredith Wall; Tifany Nolan
Journal:  J Ky Acad Sci       Date:  2008-03-01

2.  Disruption of interleukin-27 signaling results in impaired gamma interferon production but does not significantly affect immunopathology in murine schistosome infection.

Authors:  Mara G Shainheit; Rosita Saraceno; Lindsey E Bazzone; Laura I Rutitzky; Miguel J Stadecker
Journal:  Infect Immun       Date:  2007-04-02       Impact factor: 3.441

3.  Role of gamma interferon in the pathogenesis of severe schistosomiasis in interleukin-4-deficient mice.

Authors:  A C La Flamme; E A Patton; E J Pearce
Journal:  Infect Immun       Date:  2001-12       Impact factor: 3.441

4.  Interleukin-12 promotes pathologic liver changes and death in mice coinfected with Schistosoma mansoni and Toxoplasma gondii.

Authors:  M I Araujo; S K Bliss; Y Suzuki; A Alcaraz; E Y Denkers; E J Pearce
Journal:  Infect Immun       Date:  2001-03       Impact factor: 3.441

5.  CD18 Regulates Monocyte Hematopoiesis and Promotes Resistance to Experimental Schistosomiasis.

Authors:  Camila O S Souza; Milena S Espíndola; Caroline Fontanari; Morgana K B Prado; Fabiani G Frantz; Vanderlei Rodrigues; Luiz G Gardinassi; Lúcia H Faccioli
Journal:  Front Immunol       Date:  2018-08-31       Impact factor: 7.561

6.  Regulation of innate responses during pre-patent schistosome infection provides an immune environment permissive for parasite development.

Authors:  Diana K Riner; Christine E Ferragine; Sean K Maynard; Stephen J Davies
Journal:  PLoS Pathog       Date:  2013-10-10       Impact factor: 6.823

Review 7.  Current Understanding of Immunity Against Schistosomiasis: Impact on Vaccine and Drug Development.

Authors:  Adebayo J Molehin
Journal:  Res Rep Trop Med       Date:  2020-11-02
  7 in total

北京卡尤迪生物科技股份有限公司 © 2022-2023.