Literature DB >> 11119547

Group A streptococcal rofA gene is involved in the control of several virulence genes and eukaryotic cell attachment and internalization.

S Beckert1, B Kreikemeyer, A Podbielski.   

Abstract

The serotype M6 group A streptococcal RofA regulator was previously shown to exert a direct positive control of protein F1 expression and, concomitantly, fibronectin binding. Using a serotype M6 rofA mutant, we demonstrate here that this regulator has a potentially indirect negative influence on the expression of the mga, emm6, pel-sagA, and speA virulence genes. Additionally, the rofA mutant exhibited reduced eukaryotic cell internalization rates in combination with decreased host cell viability.

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Year:  2001        PMID： 11119547      PMCID： PMC97913          DOI： 10.1128/IAI.69.1.534-537.2001

Source DB:  PubMed          Journal:  Infect Immun        ISSN： 0019-9567            Impact factor:   3.441


  35 in total

Review 1.  Multiple adhesins of streptococci.

Authors:  D L Hasty; I Ofek; H S Courtney; R J Doyle
Journal:  Infect Immun       Date:  1992-06       Impact factor: 3.441

2.  Distribution and antigenicity of fibronectin binding proteins (SfbI and SfbII) of Streptococcus pyogenes clinical isolates from the northern territory, Australia.

Authors:  A M Goodfellow; M Hibble; S R Talay; B Kreikemeyer; B J Currie; K S Sriprakash; G S Chhatwal
Journal:  J Clin Microbiol       Date:  2000-01       Impact factor: 5.948

3.  Two distinct pathways for the invasion of Streptococcus pyogenes in non-phagocytic cells.

Authors:  G Molinari; M Rohde; C A Guzmán; G S Chhatwal
Journal:  Cell Microbiol       Date:  2000-04       Impact factor: 3.715

4.  Regulation of mga transcription in the group A streptococcus: specific binding of mga within its own promoter and evidence for a negative regulator.

Authors:  K S McIver; A S Thurman; J R Scott
Journal:  J Bacteriol       Date:  1999-09       Impact factor: 3.490

5.  Protein F, a fibronectin-binding protein, is an adhesin of the group A streptococcus Streptococcus pyogenes.

Authors:  E Hanski; M Caparon
Journal:  Proc Natl Acad Sci U S A       Date:  1992-07-01       Impact factor: 11.205

6.  Fibronectin-binding protein of Streptococcus pyogenes: sequence of the binding domain involved in adherence of streptococci to epithelial cells.

Authors:  S R Talay; P Valentin-Weigand; P G Jerlström; K N Timmis; G S Chhatwal
Journal:  Infect Immun       Date:  1992-09       Impact factor: 3.441

7.  Identification of a fibronectin-binding protein as adhesin of Streptococcus pyogenes.

Authors:  P Valentin-Weigand; S R Talay; K N Timmis; G S Chhatwal
Journal:  Zentralbl Bakteriol       Date:  1993-04

8.  Novel streptococcal-integration shuttle vectors for gene cloning and inactivation.

Authors:  L Tao; D J LeBlanc; J J Ferretti
Journal:  Gene       Date:  1992-10-12       Impact factor: 3.688

9.  Expression of protein F, the fibronectin-binding protein of Streptococcus pyogenes JRS4, in heterologous streptococcal and enterococcal strains promotes their adherence to respiratory epithelial cells.

Authors:  E Hanski; P A Horwitz; M G Caparon
Journal:  Infect Immun       Date:  1992-12       Impact factor: 3.441

10.  A major surface protein on group A streptococci is a glyceraldehyde-3-phosphate-dehydrogenase with multiple binding activity.

Authors:  V Pancholi; V A Fischetti
Journal:  J Exp Med       Date:  1992-08-01       Impact factor: 14.307
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  27 in total

1.  Environmental acidification drives S. pyogenes pilus expression and microcolony formation on epithelial cells in a FCT-dependent manner.

Authors:  Andrea G O Manetti; Thomas Köller; Marco Becherelli; Scilla Buccato; Bernd Kreikemeyer; Andreas Podbielski; Guido Grandi; Immaculada Margarit
Journal:  PLoS One       Date:  2010-11-05       Impact factor: 3.240

2.  Genetic characterization and virulence role of the RALP3/LSA locus upstream of the streptolysin s operon in invasive M1T1 Group A Streptococcus.

Authors:  Laura A Kwinn; Arya Khosravi; Ramy K Aziz; Anjuli M Timmer; Kelly S Doran; Malak Kotb; Victor Nizet
Journal:  J Bacteriol       Date:  2006-11-17       Impact factor: 3.490

3.  Fibronectin-binding protein gene recombination and horizontal transfer between group A and G streptococci.

Authors:  Rebecca J Towers; Daniel Gal; David McMillan; Kadaba S Sriprakash; Bart J Currie; Mark J Walker; Gursharan S Chhatwal; Peter K Fagan
Journal:  J Clin Microbiol       Date:  2004-11       Impact factor: 5.948

4.  Population genetics and linkage analysis of loci within the FCT region of Streptococcus pyogenes.

Authors:  Zerina Kratovac; Anand Manoharan; Feng Luo; Sergio Lizano; Debra E Bessen
Journal:  J Bacteriol       Date:  2006-10-06       Impact factor: 3.490

Review 5.  Streptococcus adherence and colonization.

Authors:  Angela H Nobbs; Richard J Lamont; Howard F Jenkinson
Journal:  Microbiol Mol Biol Rev       Date:  2009-09       Impact factor: 11.056

6.  Convergence of regulatory networks on the pilus locus of Streptococcus pneumoniae.

Authors:  Jason W Rosch; Beth Mann; Justin Thornton; Jack Sublett; Elaine Tuomanen
Journal:  Infect Immun       Date:  2008-04-28       Impact factor: 3.441

7.  Rgg regulates growth phase-dependent expression of proteins associated with secondary metabolism and stress in Streptococcus pyogenes.

Authors:  Michelle A Chaussee; Eduardo A Callegari; Michael S Chaussee
Journal:  J Bacteriol       Date:  2004-11       Impact factor: 3.490

8.  Identification of a streptolysin S-associated gene cluster and its role in the pathogenesis of Streptococcus iniae disease.

Authors:  Jeffrey D Fuller; Alvin C Camus; Carla L Duncan; Victor Nizet; Darrin J Bast; Ronald L Thune; Donald E Low; Joyce C S De Azavedo
Journal:  Infect Immun       Date:  2002-10       Impact factor: 3.441

9.  Analysis of RogB-controlled virulence mechanisms and gene repression in Streptococcus agalactiae.

Authors:  Heike Gutekunst; Bernhard J Eikmanns; Dieter J Reinscheid
Journal:  Infect Immun       Date:  2003-09       Impact factor: 3.441

10.  TrxR, a new CovR-repressed response regulator that activates the Mga virulence regulon in group A Streptococcus.

Authors:  Temekka V Leday; Kathryn M Gold; Traci L Kinkel; Samantha A Roberts; June R Scott; Kevin S McIver
Journal:  Infect Immun       Date:  2008-08-04       Impact factor: 3.441
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