Literature DB >> 11118626

Genetic analysis of the gene cluster for the synthesis of serotype a-specific polysaccharide antigen in Aactinobacillus actinomycetemcomitans.

N Suzuki1, Y Nakano, Y Yoshida, H Nakao, Y Yamashita, T Koga.   

Abstract

The serotype a-specific polysaccharide antigen (SPA) of Actinobacillus actinomycetemcomitans consists of 6-deoxy-D-talose. A gene cluster associated with the biosynthesis of SPA was cloned and sequenced from the chromosomal DNA of A. actinomycetemcomitans SUNYaB 75 (serotype a). This cluster consisted of 14 open reading frames. Insertional inactivation of eight genes in this cluster resulted in loss of the ability of A. actinomycetemcomitans SUNYaB 75 cells to produce the polysaccharide. A protein database search revealed that the 11 sequential genes containing these eight genes were not found in SPA-associated gene clusters of the other serotypes of A. actinomycetemcomitans. These results suggest that the gene cluster is unique to serotype a and is essential to the synthesis of the SPA.

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Year:  2000        PMID： 11118626     DOI： 10.1016/s0167-4781(00)00229-3

Source DB:  PubMed          Journal:  Biochim Biophys Acta        ISSN： 0006-3002


  8 in total

1.  Identification of Actinobacillus actinomycetemcomitans serotypes by multiplex PCR.

Authors:  N Suzuki; Y Nakano; Y Yoshida; D Ikeda; T Koga
Journal:  J Clin Microbiol       Date:  2001-05       Impact factor: 5.948

2.  Actinobacillus actinomycetemcomitans serotype d-specific antigen contains the O antigen of lipopolysaccharide.

Authors:  Laura Lakio; Susanna Paju; Georg Alfthan; Terttu Tiirola; Sirkka Asikainen; Pirkko J Pussinen
Journal:  Infect Immun       Date:  2003-09       Impact factor: 3.441

3.  Structural and genetic analyses of O polysaccharide from Actinobacillus actinomycetemcomitans serotype f.

Authors:  J B Kaplan; M B Perry; L L MacLean; D Furgang; M E Wilson; D H Fine
Journal:  Infect Immun       Date:  2001-09       Impact factor: 3.441

4.  Actinobacillus actinomycetemcomitans outer membrane protein 100 triggers innate immunity and production of beta-defensin and the 18-kilodalton cationic antimicrobial protein through the fibronectin-integrin pathway in human gingival epithelial cells.

Authors:  Kazuhisa Ouhara; Hitoshi Komatsuzawa; Hideki Shiba; Yushi Uchida; Toshihisa Kawai; Koji Sayama; Koji Hashimoto; Martin A Taubman; Hidemi Kurihara; Motoyuki Sugai
Journal:  Infect Immun       Date:  2006-09       Impact factor: 3.441

Review 5.  ABC transporters involved in export of cell surface glycoconjugates.

Authors:  Leslie Cuthbertson; Veronica Kos; Chris Whitfield
Journal:  Microbiol Mol Biol Rev       Date:  2010-09       Impact factor: 11.056

6.  Actinobacillus actinomycetemcomitans serotype b lipopolysaccharide mediates coaggregation with Fusobacterium nucleatum.

Authors:  Graciela Rosen; Ira Nisimov; Monica Helcer; Michael N Sela
Journal:  Infect Immun       Date:  2003-06       Impact factor: 3.441

7.  Glycosylation of the collagen adhesin EmaA of Aggregatibacter actinomycetemcomitans is dependent upon the lipopolysaccharide biosynthetic pathway.

Authors:  Gaoyan Tang; Keith P Mintz
Journal:  J Bacteriol       Date:  2010-01-08       Impact factor: 3.490

8.  Transcriptional and translational analysis of biofilm determinants of Aggregatibacter actinomycetemcomitans in response to environmental perturbation.

Authors:  Jayaleka J Amarasinghe; Frank A Scannapieco; Elaine M Haase
Journal:  Infect Immun       Date:  2009-05-11       Impact factor: 3.441
  8 in total

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