Literature DB >> 11118395

Choosing a route of administration for quadrivalent meningococcal polysaccharide vaccine: intramuscular versus subcutaneous.

F L Ruben1, J E Froeschle, C Meschievitz, K Chen, J George, M K Reeves-Hoché, P Pietrobon, M Bybel, W C Livingood, L Woodhouse.   

Abstract

A clinical trial was conducted to compare intramuscular (im) with subcutaneous (sc) routes for administration of quadrivalent meningococcal polysaccharide vaccine in 141 adults. Safety assessment showed the im route had reduced erythema (P<.01) and reduced headache on days 1 and 2 (P<.05). Serological testing for serum bactericidal antibody titers against capsular groups A and C did not detect significant differences.

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Year:  2000        PMID： 11118395     DOI： 10.1086/317553

Source DB:  PubMed          Journal:  Clin Infect Dis        ISSN： 1058-4838            Impact factor:   9.079


  8 in total

Review 1.  Effect of vaccine administration modality on immunogenicity and efficacy.

Authors:  Lu Zhang; Wei Wang; Shixia Wang
Journal:  Expert Rev Vaccines       Date:  2015-08-27       Impact factor: 5.217

2.  Size of the needle for infant vaccination.

Authors:  Richard Kent Zimmerman
Journal:  BMJ       Date:  2006-09-16

3.  Effect of needle size on immunogenicity and reactogenicity of vaccines in infants: randomised controlled trial.

Authors:  Linda Diggle; Jonathan J Deeks; Andrew J Pollard
Journal:  BMJ       Date:  2006-08-04

4.  Inactivated HSV-2 in MPL/alum adjuvant provides nearly complete protection against genital infection and shedding following long term challenge and rechallenge.

Authors:  Christopher S Morello; Kimberly A Kraynyak; Michael S Levinson; Zhijiang Chen; Kuo-Fen Lee; Deborah H Spector
Journal:  Vaccine       Date:  2012-09-01       Impact factor: 3.641

5.  Safety and immunogenicity of an HIV adenoviral vector boost after DNA plasmid vaccine prime by route of administration: a randomized clinical trial.

Authors:  Beryl A Koblin; Martin Casapia; Cecilia Morgan; Li Qin; Zhixue Maggie Wang; Olivier D Defawe; Lindsey Baden; Paul Goepfert; Georgia D Tomaras; David C Montefiori; M Juliana McElrath; Lilian Saavedra; Chuen-Yen Lau; Barney S Graham
Journal:  PLoS One       Date:  2011-09-12       Impact factor: 3.240

6.  Safety and immunogenicity of a Herpes Zoster subunit vaccine in Japanese population aged ≥50 years when administered subcutaneously vs. intramuscularly.

Authors:  Peter Vink; Masanari Shiramoto; Masayuki Ogawa; Masahiro Eda; Martine Douha; Thomas Heineman; Himal Lal
Journal:  Hum Vaccin Immunother       Date:  2016-12-09       Impact factor: 3.452

7.  Immune response, antibody persistence, and safety of a single dose of the quadrivalent meningococcal serogroups A, C, W-135, and Y tetanus toxoid conjugate vaccine in adolescents and adults: results of an open, randomised, controlled study.

Authors:  Charissa Borja-Tabora; Cecilia Montalban; Ziad A Memish; Marie Van der Wielen; Veronique Bianco; Dominique Boutriau; Jacqueline Miller
Journal:  BMC Infect Dis       Date:  2013-03-05       Impact factor: 3.090

Review 8.  Subcutaneous vaccine administration - an outmoded practice.

Authors:  Ian F Cook
Journal:  Hum Vaccin Immunother       Date:  2020-09-29       Impact factor: 3.452
  8 in total

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