Literature DB >> 11117507

Up-regulation of glial cell line-derived neurotrophic factor (GDNF) following traumatic spinal cord injury.

K Satake1, Y Matsuyama, M Kamiya, H Kawakami, H Iwata, K Adachi, K Kiuchi.   

Abstract

We investigated the temporal and spatial expression patterns of the GDNF gene after subjecting rats to an acute contusion injury of the spinal cord using the weight drop technique. Reverse transcriptase-polymerase chain reaction (RT-PCR) revealed that GDNF transcription in the spinal cord began to increase within 30 min after injury and peaked within 3 h. Immunohistochemical analysis showed GDNF immunoreactivity to be present mainly in microglia and macrophages 1 day after injury, but not in neurons or astrocytes. This immediate upregulation of GDNF gene expression may be a component of an inflammatory process and probably exerts a protective effect on neurons following spinal cord injury (SCI).

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Year:  2000        PMID： 11117507     DOI： 10.1097/00001756-200011270-00054

Source DB:  PubMed          Journal:  Neuroreport        ISSN： 0959-4965            Impact factor:   1.837


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