| Literature DB >> 11116185 |
P Cohen1.
Abstract
The phosphorylation of a protein can alter its behaviour in almost every conceivable way. These include modulation of its intrinsic biological activity, subcellular location, half-life and docking with other proteins. 'Multisite phosphorylation can enable several such effects to operate in the same protein. It can also determine the extent and duration of a response and is the key to signal integration.Mesh:
Substances:
Year: 2000 PMID: 11116185 DOI: 10.1016/s0968-0004(00)01712-6
Source DB: PubMed Journal: Trends Biochem Sci ISSN: 0968-0004 Impact factor: 13.807