| Literature DB >> 11115672 |
G Pinzón-Duarte1, K Kohler, B Arango-González, E Guenther.
Abstract
This study was focused on the analysis of cell type differentiation and synaptogenesis as well as outer segment formation in an organotypic culture of the neonatal rat retina during a 6-14 day period of in vitro development. Moreover, the effects of the retinal pigment epithelium (RPE) on these processes were investigated. The in vitro development resulted in a retinal architecture and lamination comparable to that of in vivo retinas. The RPE influences the proper alignment of photoreceptors as well as the formation of the outer limiting membrane (OLM), but not processes of cell differentiation, synaptogenesis and inner retinal lamination.Entities:
Mesh：
Year: 2000 PMID： 11115672 DOI： 10.1016/s0042-6989(00)00185-1
Source DB: PubMed Journal: Vision Res ISSN： 0042-6989 Impact factor: 1.886