Literature DB >> 1111489

Teratogenicities of ophthalmic drugs. II. Teratogenicities and tissue accumulation of thimerosal.

A R Gasset, M Itoi, Y Ishii, R M Ramer.   

Abstract

Under the conditions of this study, systemically or topically applied thimerosal was found to have no teratogenic effect even when given in concentrations approaching the 50% lethal dose of these compounds. A comparison of topical and subcutaneous administration of thimerosal to rabbits shows that a substantial concentration of mercury was present in blood and tissues of the treated animals and their offspring. Thimerosal was found to cross the blood-brain and placenta barriers.

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Year:  1975        PMID: 1111489     DOI: 10.1001/archopht.1975.01010020056010

Source DB:  PubMed          Journal:  Arch Ophthalmol        ISSN: 0003-9950


  3 in total

Review 1.  Trifluridine: a review of its antiviral activity and therapeutic use in the topical treatment of viral eye infections.

Authors:  A A Carmine; R N Brogden; R C Heel; T M Speight; G S Avery
Journal:  Drugs       Date:  1982-05       Impact factor: 9.546

Review 2.  Integrating experimental (in vitro and in vivo) neurotoxicity studies of low-dose thimerosal relevant to vaccines.

Authors:  José G Dórea
Journal:  Neurochem Res       Date:  2011-02-25       Impact factor: 4.414

3.  Comparison of VAERS fetal-loss reports during three consecutive influenza seasons: was there a synergistic fetal toxicity associated with the two-vaccine 2009/2010 season?

Authors:  G S Goldman
Journal:  Hum Exp Toxicol       Date:  2012-09-27       Impact factor: 2.903

  3 in total

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