| Literature DB >> 11114423 |
A F Ochsenbein1, R M Zinkernagel.
Abstract
Natural or spontaneous antibodies are an essential part of the first line of defense against hematogenically spreading infections, including viruses. These antibodies target virus-antibody complexes and complement to the spleen. This prevents infections from reaching vital organs and enhances neutralizing antibody responses, particularly when the antibody is bound to a highly repetitive antigen.Entities:
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Year: 2000 PMID: 11114423 DOI: 10.1016/s0167-5699(00)01754-0
Source DB: PubMed Journal: Immunol Today ISSN: 0167-5699