Literature DB >> 11114420

The ITAM-bearing transmembrane adaptor DAP12 in lymphoid and myeloid cell function.

L L Lanier1, A B Bakker.   

Abstract

DAP12, an ITAM-bearing transmembrane adaptor protein, associates non-covalently with receptors in natural killer (NK) and myeloid cells, and provides signaling function via the Syk and ZAP-70 tyrosine kinase activation pathways. Humans and mice lacking DAP12 (DAP12(-/-)) show normal development of hematopoietic cells. However, DAP12(-/-) humans develop presenile dementia and bone cysts, and DAP12(-/-) mice show impaired immune responses.

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Year:  2000        PMID： 11114420     DOI： 10.1016/s0167-5699(00)01745-x

Source DB:  PubMed          Journal:  Immunol Today        ISSN： 0167-5699


  65 in total

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Authors:  Marco Colonna
Journal:  J Clin Invest       Date:  2003-02       Impact factor: 14.808

2.  Novel immunoglobulin-like transcripts in teleost fish encode polymorphic receptors with cytoplasmic ITAM or ITIM and a new structural Ig domain similar to the natural cytotoxicity receptor NKp44.

Authors:  René J M Stet; Trudi Hermsen; Adrie H Westphal; Jojanneke Jukes; Marc Engelsma; B M Lidy Verburg-van Kemenade; Jos Dortmans; Joao Aveiro; Huub F J Savelkoul
Journal:  Immunogenetics       Date:  2005-02-09       Impact factor: 2.846

3.  Enhanced Toll-like receptor responses in the absence of signaling adaptor DAP12.

Authors:  Jessica A Hamerman; Nadia K Tchao; Clifford A Lowell; Lewis L Lanier
Journal:  Nat Immunol       Date:  2005-05-15       Impact factor: 25.606

4.  CLEC5A (MDL-1) is a novel PU.1 transcriptional target during myeloid differentiation.

Authors:  Jasmin Batliner; Maria Michela Mancarelli; Mathias Jenal; Venkateshwar A Reddy; Martin F Fey; Bruce E Torbett; Mario P Tschan
Journal:  Mol Immunol       Date:  2010-11-20       Impact factor: 4.407

5.  DAP12 couples c-Fms activation to the osteoclast cytoskeleton by recruitment of Syk.

Authors:  Wei Zou; Jennifer L Reeve; Yuli Liu; Steven L Teitelbaum; F Patrick Ross
Journal:  Mol Cell       Date:  2008-08-08       Impact factor: 17.970

6.  The immunomodulatory adapter proteins DAP12 and Fc receptor gamma-chain (FcRgamma) regulate development of functional osteoclasts through the Syk tyrosine kinase.

Authors:  Attila Mócsai; Mary Beth Humphrey; Jessica A G Van Ziffle; Yongmei Hu; Andrew Burghardt; Steven C Spusta; Sharmila Majumdar; Lewis L Lanier; Clifford A Lowell; Mary C Nakamura
Journal:  Proc Natl Acad Sci U S A       Date:  2004-04-08       Impact factor: 11.205

7.  Allostimulatory activity of bone marrow-derived plasmacytoid dendritic cells is independent of indoleamine dioxygenase but regulated by inducible costimulator ligand expression.

Authors:  Bridget L Colvin; Tina L Sumpter; Daisuke Tokita; Jennifer Salati; Andrew L Mellor; Angus W Thomson
Journal:  Hum Immunol       Date:  2009-02-03       Impact factor: 2.850

Review 8.  Osteoclast motility: putting the brakes on bone resorption.

Authors:  Deborah V Novack; Roberta Faccio
Journal:  Ageing Res Rev       Date:  2009-09-27       Impact factor: 10.895

Review 9.  A Comprehensive Review of Immunoreceptor Regulation of Osteoclasts.

Authors:  Mary Beth Humphrey; Mary C Nakamura
Journal:  Clin Rev Allergy Immunol       Date:  2016-08       Impact factor: 8.667

10.  Pattern of DAP12 expression in leukocytes from both healthy and systemic lupus erythematosus patients.

Authors:  Nicolas Schleinitz; Laurent Chiche; Sophie Guia; Gaëlle Bouvier; Julie Vernier; Alexis Morice; Elisabeth Houssaint; Jean Robert Harlé; Gilles Kaplanski; Félix A Montero-Julian; Frédéric Vély
Journal:  PLoS One       Date:  2009-07-16       Impact factor: 3.240
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