Literature DB >> 11114102

Insulin receptor substrate (IRS) transduction system: distinct and overlapping signaling potential.

B Giovannone1, M L Scaldaferri, M Federici, O Porzio, D Lauro, A Fusco, P Sbraccia, P Borboni, R Lauro, G Sesti.   

Abstract

Insulin receptor substrate (IRS) proteins play a central role in maintaining basic cellular functions such as growth and metabolism. They act as an interface between multiple growth factor receptors possessing tyrosine kinase activity, such as the insulin receptor, and a complex network of intracellular signalling molecules containing Src homology 2 (SH2) domains. Four members (IRS-1, IRS-2, IRS-3, IRS-4) of this family have been identified which differ in their subcellular distribution and interaction with SH2 domain proteins. In addition, differential IRS tissue- and developmental-specific expression patterns may contribute to specificity in their signaling potential. Copyright 2000 John Wiley & Sons, Ltd.

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Year:  2000        PMID： 11114102     DOI： 10.1002/1520-7560(2000)9999:9999<::aid-dmrr159>3.0.co;2-8

Source DB:  PubMed          Journal:  Diabetes Metab Res Rev        ISSN： 1520-7552            Impact factor:   4.876


  41 in total

1.  Over-expression of LYRM1 inhibits glucose transport in rat skeletal muscles via attenuated phosphorylation of PI3K (p85) and Akt.

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Journal:  Mol Cell Biochem       Date:  2010-11-12       Impact factor: 3.396

2.  Aflatoxin B1 induces Src phosphorylation and stimulates lung cancer cell migration.

Authors:  Anguo Cui; Hui Hua; Ting Shao; Peiying Song; Qingbin Kong; Ting Luo; Yangfu Jiang
Journal:  Tumour Biol       Date:  2015-03-29

3.  Angiotensin II modulates tyr-phosphorylation of IRS-4, an insulin receptor substrate, in rat liver membranes.

Authors:  Rodrigo S Villarreal; Sergio E Alvarez; Maximiliano Juri Ayub; Gladys M Ciuffo
Journal:  Mol Cell Biochem       Date:  2006-08-24       Impact factor: 3.396

4.  Lipid Raft targeting of the TC10 amino terminal domain is responsible for disruption of adipocyte cortical actin.

Authors:  June Chunqiu Hou; Jeffrey E Pessin
Journal:  Mol Biol Cell       Date:  2003-07-25       Impact factor: 4.138

5.  Over-expression of NYGGF4 inhibits glucose transport in 3T3-L1 adipocytes via attenuated phosphorylation of IRS-1 and Akt.

Authors:  Chun-mei Zhang; Xiao-hui Chen; Bin Wang; Feng Liu; Xia Chi; Mei-ling Tong; Yu-hui Ni; Rong-hua Chen; Xi-rong Guo
Journal:  Acta Pharmacol Sin       Date:  2008-12-15       Impact factor: 6.150

6.  The pleckstrin homology (PH) domain-interacting protein couples the insulin receptor substrate 1 PH domain to insulin signaling pathways leading to mitogenesis and GLUT4 translocation.

Authors:  Janet Farhang-Fallah; Varinder K Randhawa; Anjaruwee Nimnual; Amira Klip; Dafna Bar-Sagi; Maria Rozakis-Adcock
Journal:  Mol Cell Biol       Date:  2002-10       Impact factor: 4.272

Review 7.  Insulin resistance and neurodegeneration: roles of obesity, type 2 diabetes mellitus and non-alcoholic steatohepatitis.

Authors:  Suzanne M de la Monte; Lisa Longato; Ming Tong; Jack R Wands
Journal:  Curr Opin Investig Drugs       Date:  2009-10

Review 8.  Defect of insulin signal in peripheral tissues: Important role of ceramide.

Authors:  Rima Hage Hassan; Olivier Bourron; Eric Hajduch
Journal:  World J Diabetes       Date:  2014-06-15

Review 9.  Insulin resistance and Alzheimer's disease.

Authors:  Suzanne M de la Monte
Journal:  BMB Rep       Date:  2009-08-31       Impact factor: 4.778

Review 10.  The liver-brain axis of alcohol-mediated neurodegeneration: role of toxic lipids.

Authors:  Suzanne M de la Monte; Lisa Longato; Ming Tong; Sarah DeNucci; Jack R Wands
Journal:  Int J Environ Res Public Health       Date:  2009-07-23       Impact factor: 3.390
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