| Literature DB >> 11112640 |
S F Brady1, M P Singh, J E Janso, J Clardy.
Abstract
[structure] The biochemical induction assay (BIA) is a rapid (colorimetric) bacterial assay used to identify compounds that damage DNA or inhibit DNA synthesis and thereby identify potential natural product anticancer agents. Bisanthraquinones based on a 1,3,6, 8-tetrahydroxyanthraquinone-type carbon skeleton were isolated from an endophytic fungus and characterized by NMR and X-ray crystallography. Cytoskyrin A (1) is highly active in the biochemical induction assay, while the closely related cytoskyrin B (2) has no detectable activity in this assay.Entities:
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Year: 2000 PMID： 11112640 DOI： 10.1021/ol006681k
Source DB: PubMed Journal: Org Lett ISSN： 1523-7052 Impact factor: 6.005