| Literature DB >> 11112639 |
S F Brady1, M M Wagenaar, M P Singh, J E Janso, J Clardy.
Abstract
[structure] Organic extracts from cultures of endophytic fungi collected in the Guanacaste Conservation Area of Costa Rica were screened for antibiotic activity. Two endophytes CR200 (Cytospora sp.) and CR146 (Diaporthe sp.) were found to have potent antibiotic activity. Bioassay-guided fractionation of the extracts from these fungi led to the identification of cytosporones D and E, antibacterial active trihydroxybenzene lactones, and three related but inactive metabolites. The five new octaketides were characterized using X-ray crystallography and NMR.Entities:
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Year: 2000 PMID： 11112639 DOI： 10.1021/ol006680s
Source DB: PubMed Journal: Org Lett ISSN： 1523-7052 Impact factor: 6.005