Literature DB >> 11112626

2'-O-[2-[N,N-(dialkyl)aminooxy]ethyl]-modified antisense oligonucleotides.

T P Prakash1, M Manoharan, A M Kawasaki, E A Lesnik, S R Owens, G Vasquez.   

Abstract

[structure] Oligonucleotides with two novel modifications, 2'-O-¿2-[N, N-(dimethyl)aminooxy]ethyl¿ (2'-O-DMAOE) and 2'-O-¿2-[N, N-(diethyl)aminooxy]ethyl¿ (2'-O-DEAOE), have been synthesized. These modifications exhibit high binding affinity to target RNA (and not to DNA) and enhance the nuclease stability of oligonucleotides considerably with t(1/2) > 24 h as a phosphodiester.

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Year:  2000        PMID： 11112626     DOI： 10.1021/ol006555g

Source DB:  PubMed          Journal:  Org Lett        ISSN： 1523-7052            Impact factor:   6.005


  2 in total

1.  2'-O-[2-[(N,N-dimethylamino)oxy]ethyl]-modified oligonucleotides inhibit expression of mRNA in vitro and in vivo.

Authors:  Thazha P Prakash; Joseph F Johnston; Mark J Graham; Thomas P Condon; Muthiah Manoharan
Journal:  Nucleic Acids Res       Date:  2004-02-03       Impact factor: 16.971

2.  Aminooxy Click Chemistry as a Tool for Bis-homo and Bis-hetero Ligand Conjugation to Nucleic Acids.

Authors:  Dhrubajyoti Datta; Shohei Mori; Mimouna Madaoui; Kelly Wassarman; Ivan Zlatev; Muthiah Manoharan
Journal:  Org Lett       Date:  2022-06-17       Impact factor: 6.072
  2 in total

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