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Literature DB >> 11112616

Design and synthesis of novel [60]fullerene derivatives as potential HIV aspartic protease inhibitors.

G L Marcorin¹, T Da Ros, S Castellano, G Stefancich, I Bonin, S Miertus, M Prato.

Abstract

[structure] Two water-soluble fullerene derivatives have been computer-designed and synthesized. They may exhibit interesting anti-HIV activity owing to the presence of two ammonium groups strategically located on the spheroid surface.

Entities: Chemical

Mesh：

Substances：

Year: 2000 PMID： 11112616 DOI： 10.1021/ol000217y

Source DB: PubMed Journal: Org Lett ISSN： 1523-7052 Impact factor: 6.005

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Cited

10 in total

1. Fullerene Derivatives Strongly Inhibit HIV-1 Replication by Affecting Virus Maturation without Impairing Protease Activity.

Authors: Zachary S Martinez; Edison Castro; Chang-Soo Seong; Maira R Cerón; Luis Echegoyen; Manuel Llano
Journal: Antimicrob Agents Chemother Date: 2016-09-23 Impact factor: 5.191

2. Synthesis and biological evaluation of cationic fullerene quinazolinone conjugates and their binding mode with modeled Mycobacterium tuberculosis hypoxanthine-guanine phosphoribosyltransferase enzyme.

Authors: Manishkumar B Patel; Sivakumar Prasanth Kumar; Nikunj N Valand; Yogesh T Jasrai; Shobhana K Menon
Journal: J Mol Model Date: 2013-04-30 Impact factor: 1.810

Design and synthesis of novel [60]fullerene derivatives as potential HIV aspartic protease inhibitors.

1. Fullerene Derivatives Strongly Inhibit HIV-1 Replication by Affecting Virus Maturation without Impairing Protease Activity.

2. Synthesis and biological evaluation of cationic fullerene quinazolinone conjugates and their binding mode with modeled Mycobacterium tuberculosis hypoxanthine-guanine phosphoribosyltransferase enzyme.

Review 3. Biomedical applications of functionalized fullerene-based nanomaterials.

4. Interaction of human serum album and C₆₀ aggregates in solution.

5. C₆₀ Bioconjugation with Proteins: Towards a Palette of Carriers for All pH Ranges.

6. Effect of C₆₀ on the phase transition behavior of a lipid bilayer under high pressure.

7. Toxic Effect of Fullerene and Its Derivatives upon the Transmembrane β₂-Adrenergic Receptors.

Review 8. Progress in Antiviral Fullerene Research.

Review 9. Medicinal applications of fullerenes.

10. Fullerenes against COVID-19: Repurposing C₆₀ and C₇₀ to Clog the Active Site of SARS-CoV-2 Protease.