| Literature DB >> 11112557 |
I W Davies1, J F Marcoux, E G Corley, M Journet, D W Cai, M Palucki, J Wu, R D Larsen, K Rossen, P J Pye, L DiMichele, P Dormer, P J Reider.
Abstract
A number of synthetic strategies to the Cox-2 specific inhibitor 1 have been described. These studies have led to the identification of a novel pyridine construction using annulation of ketone 2 using a vinamidinium species 29 and ammonia in 97% assay yield. Three approaches to the synthesis of ketone 2 are described that allow for its preparation in large quantities in >65% overall yield from methyl 6-methylnicotinate.Entities:
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Year: 2000 PMID： 11112557 DOI： 10.1021/jo000870z
Source DB: PubMed Journal: J Org Chem ISSN： 0022-3263 Impact factor: 4.354