| Literature DB >> 11112421 |
M J Barrero1, P F Marrero, D Haro.
Abstract
L-CPT I isotype is the main locus of control for liver LCFA oxidation. T3 levels have been described as controlling L-CPT I gene expression, and in this paper we demonstrate that rat liver CPT I promoter responds to T3. Using deleted reporter constructs we located the thyroid hormone-responsive element between -2935 and -2918, consisting of a DR4. This response is mediated by the binding of the thyroid to this sequence as a monomer, homodimer, or heterodimer with RXR. Copyright 2000 Academic Press.Entities:
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Year: 2000 PMID： 11112421 DOI： 10.1006/bbrc.2000.3893
Source DB: PubMed Journal: Biochem Biophys Res Commun ISSN： 0006-291X Impact factor: 3.575