Q Ye1, L Gu, J Zhao, A Liang, Y Ye. 1. Department of Pediatric Hematology/ Oncology, Xinhua Hospital/Shanghai Childrenns Medical Center, Shanghai Second Medical University, Shanghai, 200092 P.R.China. yeqidong@yahoo.com
Abstract
OBJECTIVE: To gain an insight into the hereditary polymorphism of thiopurine methyltransferase(TPMT) activity in Chinese Han population of Shanghai. METHODS: The present authors measured the erythrocyte TPMT activity in 320 healthy Chinese volunteers and 51 children with acute lymphoblastic leukemia(ALL) by means of radiochemical assay. RESULTS: The TPMT activity levels ranged from 4. 32 to 32.33 U/ml pRBCs, with a mean value of (16.64+/-4.50) U/ml pRBCs, male (16.78+/-4.96) U/ml pRBCs, female (16.52+/-4.44) U/ml pRBCs. Eight point one percent of the sample had low activity. The TPMT activity levels for subjects who were <12 years, 13-18 years, 19-45 years and >45 years old were (16.52+/-4.31) U/ml pRBCs, (16. 71+/-4.24) U/ml pRBCs, (16.28+/-5.21) U/ml pRBCs and (17.11+/-3.98) U/ml pRBCs, respectively; the TPMT activity levels for healthy volunteers and patients with ALL were (16.65+/-4.72) U/ml pRBCs and (16.52+/-4.47) U/ml pRBCs, respectively. CONCLUSION: There were no differences of TPMT activity in gender, age, and between healthy volunteers and patients with ALL.
OBJECTIVE: To gain an insight into the hereditary polymorphism of thiopurine methyltransferase(TPMT) activity in Chinese Han population of Shanghai. METHODS: The present authors measured the erythrocyte TPMT activity in 320 healthy Chinese volunteers and 51 children with acute lymphoblastic leukemia(ALL) by means of radiochemical assay. RESULTS: The TPMT activity levels ranged from 4. 32 to 32.33 U/ml pRBCs, with a mean value of (16.64+/-4.50) U/ml pRBCs, male (16.78+/-4.96) U/ml pRBCs, female (16.52+/-4.44) U/ml pRBCs. Eight point one percent of the sample had low activity. The TPMT activity levels for subjects who were <12 years, 13-18 years, 19-45 years and >45 years old were (16.52+/-4.31) U/ml pRBCs, (16. 71+/-4.24) U/ml pRBCs, (16.28+/-5.21) U/ml pRBCs and (17.11+/-3.98) U/ml pRBCs, respectively; the TPMT activity levels for healthy volunteers and patients with ALL were (16.65+/-4.72) U/ml pRBCs and (16.52+/-4.47) U/ml pRBCs, respectively. CONCLUSION: There were no differences of TPMT activity in gender, age, and between healthy volunteers and patients with ALL.