PURPOSE: To combine three magnetic resonance (MR) imaging modalities-dobutamine stress cine, first pass, and late contrast material-enhanced T1-weighted imaging-and to compare the results with 2-[fluorine 18]fluoro-2-deoxy-D-glucose (FDG) positron emission tomography (PET) in the assessment of unviable myocardium in coronary artery disease. MATERIALS AND METHODS: Ten patients with multivessel coronary artery disease underwent MR imaging before and 6 months after bypass surgery. Left ventricular cine MR imaging was performed at rest and during dobutamine infusion. Inversion-recovery gradient-echo images were obtained to study myocardial contrast enhancement at first pass and 5 minutes later. FDG PET was performed with orally administered acipimox before surgery. RESULTS: With dobutamine cine MR imaging, unviable myocardium was detected with a sensitivity of 79% and a specificity of 93%; postoperative wall thickening was the standard. First-pass analysis increased these values to 97% and 96%; analysis of late enhancement with T1-weighted imaging, to 62% and 98%. FDG PET had a sensitivity of 81% and a specificity of 86%. CONCLUSION: The combination of first-pass enhancement analysis and wall motion assessment with stress significantly increases the specificity of MR imaging in the detection of unviable sectors.
PURPOSE: To combine three magnetic resonance (MR) imaging modalities-dobutamine stress cine, first pass, and late contrast material-enhanced T1-weighted imaging-and to compare the results with 2-[fluorine 18]fluoro-2-deoxy-D-glucose (FDG) positron emission tomography (PET) in the assessment of unviable myocardium in coronary artery disease. MATERIALS AND METHODS: Ten patients with multivessel coronary artery disease underwent MR imaging before and 6 months after bypass surgery. Left ventricular cine MR imaging was performed at rest and during dobutamine infusion. Inversion-recovery gradient-echo images were obtained to study myocardial contrast enhancement at first pass and 5 minutes later. FDG PET was performed with orally administered acipimox before surgery. RESULTS: With dobutamine cine MR imaging, unviable myocardium was detected with a sensitivity of 79% and a specificity of 93%; postoperative wall thickening was the standard. First-pass analysis increased these values to 97% and 96%; analysis of late enhancement with T1-weighted imaging, to 62% and 98%. FDG PET had a sensitivity of 81% and a specificity of 86%. CONCLUSION: The combination of first-pass enhancement analysis and wall motion assessment with stress significantly increases the specificity of MR imaging in the detection of unviable sectors.
Authors: M Gutberlet; M Fröhlich; S Mehl; H Amthauer; H Hausmann; R Meyer; H Siniawski; J Ruf; M Plotkin; T Denecke; B Schnackenburg; R Hetzer; R Felix Journal: Eur Radiol Date: 2005-03-08 Impact factor: 5.315
Authors: V Bodí; J Sanchis; M P López-Lereu; J Núñez; R Sanz; P Palau; C Gómez; D Moratal; F J Chorro; A Llácer Journal: Heart Date: 2006-06-27 Impact factor: 5.994
Authors: H Bülow; C Klein; I Kuehn; R Hollweck; S G Nekolla; K Schreiber; F Haas; J Böhm; B Schnackenburg; R Lange; M Schwaiger Journal: Heart Date: 2005-09 Impact factor: 5.994
Authors: Paula Vesterinen; Helena Hänninen; Milla Karvonen; Kirsi Lauerma; Miia Holmström; Markku Mäkijärvi; Heikki Väänänen; Jukka Nenonen; Toivo Katila; Lauri Toivonen Journal: Ann Noninvasive Electrocardiol Date: 2004-07 Impact factor: 1.468