BACKGROUND AND PURPOSE: High-dose intraarterial chemotherapy with repeated one-shot infusion may be useful for treating head and neck tumors. We evaluated the efficacy of superselective continuous arterial infusion chemotherapy administered via a coaxial catheter system and compared the results with those of subselective catheterization for treatment of oral cavity tumors. METHODS: Forty-nine consecutive patients with tumors of the oral cavity (clinical stage I, 12 cases; stage II, 19 cases; stage III, six cases; stage IV, 12 cases) were treated by arterial infusion chemotherapy. After a guiding catheter was advanced into the superficial temporal artery, superselective catheterization was performed using a coaxial system microcatheter. Superselective catheterization was accomplished in 34 cases, and was unsuccessful in 15, owing to difficulties in performing catheterization or to multiple feeding arteries. In the latter cases, the tip of the catheter was placed near the origin of the feeding arteries (subselective catheterization). RESULTS: Thirty (88%) of 34 patients had a complete response to superselective arterial infusion chemotherapy and two (6%) had a partial response. Twelve (80%) of 15 patients had a complete response to subselective arterial infusion chemotherapy and three (20%) had a partial response. Local recurrence was more frequent after subselective treatment (13%) than after superselective (6%) treatment. CONCLUSION: Superselective continuous arterial infusion chemotherapy may be suitable for local control of oral cavity tumors, with a low rate of recurrence.
BACKGROUND AND PURPOSE: High-dose intraarterial chemotherapy with repeated one-shot infusion may be useful for treating head and neck tumors. We evaluated the efficacy of superselective continuous arterial infusion chemotherapy administered via a coaxial catheter system and compared the results with those of subselective catheterization for treatment of oral cavity tumors. METHODS: Forty-nine consecutive patients with tumors of the oral cavity (clinical stage I, 12 cases; stage II, 19 cases; stage III, six cases; stage IV, 12 cases) were treated by arterial infusion chemotherapy. After a guiding catheter was advanced into the superficial temporal artery, superselective catheterization was performed using a coaxial system microcatheter. Superselective catheterization was accomplished in 34 cases, and was unsuccessful in 15, owing to difficulties in performing catheterization or to multiple feeding arteries. In the latter cases, the tip of the catheter was placed near the origin of the feeding arteries (subselective catheterization). RESULTS: Thirty (88%) of 34 patients had a complete response to superselective arterial infusion chemotherapy and two (6%) had a partial response. Twelve (80%) of 15 patients had a complete response to subselective arterial infusion chemotherapy and three (20%) had a partial response. Local recurrence was more frequent after subselective treatment (13%) than after superselective (6%) treatment. CONCLUSION: Superselective continuous arterial infusion chemotherapy may be suitable for local control of oral cavity tumors, with a low rate of recurrence.
Authors: Y Korogi; T Hirai; R Nishimura; S Hamatake; Y Sakamoto; R Murakami; Y Baba; A Arakawa; M Takahashi; Y Uji Journal: AJR Am J Roentgenol Date: 1995-11 Impact factor: 3.959
Authors: T J Ervin; J R Clark; R R Weichselbaum; B G Fallon; D Miller; R L Fabian; M R Posner; C M Norris; S A Tuttle; D A Schoenfeld Journal: J Clin Oncol Date: 1987-01 Impact factor: 44.544
Authors: G Los; f A Blommaert; R Barton; D D Heath; L den Engelse; C Hanchett; D Vicario; R Weisman; K T Robbins; S B Howell Journal: Cancer Chemother Pharmacol Date: 1995 Impact factor: 3.333
Authors: Randy S D'Amico; Deepak Khatri; Noah Reichman; Nitesh V Patel; Tamika Wong; Sherese R Fralin; Mona Li; Jason A Ellis; Rafael Ortiz; David J Langer; John A Boockvar Journal: J Neurooncol Date: 2020-02-19 Impact factor: 4.130
Authors: I Ikushima; Y Korogi; A Ishii; T Hirai; M Yamura; R Nishimura; Y Baba; Y Yamashita; M Shinohara Journal: Eur Arch Otorhinolaryngol Date: 2006-10-24 Impact factor: 2.503
Authors: Jason A Ellis; Matei Banu; Shaolie S Hossain; Rajinder Singh-Moon; Sean D Lavine; Jeffrey N Bruce; Shailendra Joshi Journal: J Drug Deliv Date: 2015-12-30