Literature DB >> 11109545

Distribution of body weight, blood insulin and lipid levels in the SMXA recombinant inbred strains and the QTL analysis.

R V Anunciado1, T Ohno, M Mori, A Ishikawa, S Tanaka, F Horio, M Nishimura, T Namikawa.   

Abstract

In the SMXA recombinant inbred (RI) strains, we measured body weight, blood insulin and lipid (triglyceride, total cholesterol and phospholipid) levels in each strain. In the five traits, mean values of substrains varied remarkably and showed a continuous spectrum of distribution, suggesting control by multiple genes at distinct loci for each trait. We also screened for quantitative trait loci (QTLs) involved in the five traits. Suggestive QTLs for body weight (Chromosomes 1 and 6), insulin (Chromosomes 1, 3, 10 and 17), triglyceride (Chromosomes 4 and 11) and phospholipid (Chromosome 18) levels were detected. The SMXA RI strains are unique tools for analyzing genetic factors that influence body weight, blood insulin and lipids levels.

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Year:  2000        PMID： 11109545     DOI： 10.1538/expanim.49.217

Source DB:  PubMed          Journal:  Exp Anim        ISSN： 0007-5124


  9 in total

1.  A large-sample QTL study in mice: I. Growth.

Authors:  Joao L Rocha; Eugene J Eisen; L Dale Van Vleck; Daniel Pomp
Journal:  Mamm Genome       Date:  2004-02       Impact factor: 2.957

2.  Architecture of energy balance traits in emerging lines of the Collaborative Cross.

Authors:  Wendy Foulds Mathes; David L Aylor; Darla R Miller; Gary A Churchill; Elissa J Chesler; Fernando Pardo-Manuel de Villena; David W Threadgill; Daniel Pomp
Journal:  Am J Physiol Endocrinol Metab       Date:  2011-03-22       Impact factor: 4.310

3.  Establishment of consomic strains derived from A/J and SM/J mice for genetic analysis of complex traits.

Authors:  Tamio Ohno; Keiko Hata; Taisuke Baba; Fusayo Io; Misato Kobayashi; Fumihiko Horio; Masahiko Nishimura
Journal:  Mamm Genome       Date:  2012-10-10       Impact factor: 2.957

4.  Quantitative trait locus analysis of atherosclerosis in an intercross between C57BL/6 and C3H mice carrying the mutant apolipoprotein E gene.

Authors:  Zhiguang Su; Yuhua Li; Jessica C James; Marcia McDuffie; Alan H Matsumoto; Gregory A Helm; James L Weber; Aldons J Lusis; Weibin Shi
Journal:  Genetics       Date:  2005-12-30       Impact factor: 4.562

5.  Major quantitative trait locus on chromosome 2 for glucose tolerance in diabetic SMXA-5 mouse established from non-diabetic SM/J and A/J strains.

Authors:  M Kobayashi; F Io; T Kawai; M Kumazawa; H Ikegami; M Nishimura; T Ohno; F Horio
Journal:  Diabetologia       Date:  2006-01-31       Impact factor: 10.122

6.  Haplotype analysis in multiple crosses to identify a QTL gene.

Authors:  Xiaosong Wang; Ron Korstanje; David Higgins; Beverly Paigen
Journal:  Genome Res       Date:  2004-08-12       Impact factor: 9.043

7.  Identification of genetic regions of importance for reproductive performance in female mice.

Authors:  Maria Liljander; Mary-Ann Sällström; Sara Andersson; Patrik Wernhoff; Asa Andersson; Rikard Holmdahl; Ragnar Mattsson
Journal:  Genetics       Date:  2006-03-17       Impact factor: 4.562

8.  Diet-induced alterations in intestinal and extrahepatic lipid metabolism in liver fatty acid binding protein knockout mice.

Authors:  Elizabeth P Newberry; Susan M Kennedy; Yan Xie; Jianyang Luo; Nicholas O Davidson
Journal:  Mol Cell Biochem       Date:  2008-12-31       Impact factor: 3.396

9.  Detection of loci for allergic asthma using SMXA recombinant inbred strains of mice.

Authors:  Tamio Ohno; Masakazu Okamoto; Toru Hara; Naozumi Hashimoto; Kazuyoshi Imaizumi; Miyoko Matsushima; Masahiko Nishimura; Kaoru Shimokata; Yoshinori Hasegawa; Tsutomu Kawabe
Journal:  Immunogenetics       Date:  2012-10-19       Impact factor: 2.846
  9 in total

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