| Literature DB >> 11106000 |
J Yun1, C K Lee, I M Chang, K Takatsu, T Hirano, K R Min, M K Lee, Y Kim.
Abstract
Effects of sophoricoside and its analogs on proinflammatory cytokines have been investigated. Sophoricoside, genistein and orobol exhibited inhibitory effects on IL-5, IL-3, GM-CSF and IL-6 bioactivities. Genistin showed inhibitory effects on IL-5 and IL-3 bioactivities, but did not inhibit GM-CSF and IL-6 bioactivities. None of the sophoricoside analogs showed inhibitory effects on both IL-1beta and TNF-alpha bioactivities. Among the compounds, sophoricoside exhibited the highest inhibitory effects on IL-5, IL-3 and IL-6 bioactivities with IC50 values of 1.9 microM, 6.9 microM and 6.0 microM, respectively and orobol did show on GM-CSF bioactivity with an IC50 value of 18.0 microM. The result would provide an additional mechanism by which the compounds exert immunosuppressive and anti-inflammatory effects.Entities:
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Year: 2000 PMID： 11106000 DOI： 10.1016/s0024-3205(00)00873-0
Source DB: PubMed Journal: Life Sci ISSN： 0024-3205 Impact factor: 5.037