Literature DB >> 11104899

Disposition characteristics of emulsions and incorporated drugs after systemic or local injection.

S Kawakami1, F Yamashita, M Hashida.   

Abstract

Lipid emulsions are useful tools for controlling the in vivo disposition of drugs and plasmid DNA. The dispositions of lipid emulsions are determined by their tissue interaction depending on the anatomical and physiological characteristics of each tissue and the physicochemical and biological properties of lipid emulsions. In addition, the retention of drugs is another issue, as too rapid a release of the drug would lead to failure of exerting its therapeutic potency. This review presents an overview about the disposition profiles and various physicochemical properties of lipid emulsions and incorporated drugs after systemic or local injection. Controlled biodistribution of lipid emulsions and incorporated drugs are also discussed.

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Year:  2000        PMID： 11104899     DOI： 10.1016/s0169-409x(00)00102-2

Source DB:  PubMed          Journal:  Adv Drug Deliv Rev        ISSN： 0169-409X            Impact factor:   15.470


  4 in total

1.  The study on the entrapment efficiency and in vitro release of puerarin submicron emulsion.

Authors:  Peng-Fei Yue; Xiu-Yun Lu; Zeng-Zhu Zhang; Hai-Long Yuan; Wei-Feng Zhu; Qin Zheng; Ming Yang
Journal:  AAPS PharmSciTech       Date:  2009-04-21       Impact factor: 3.246

2.  Phosphatidylinositol 3-kinase inhibitor (PIK75) containing surface functionalized nanoemulsion for enhanced drug delivery, cytotoxicity and pro-apoptotic activity in ovarian cancer cells.

Authors:  Meghna Talekar; Srinivas Ganta; Amit Singh; Mansoor Amiji; Jackie Kendall; William A Denny; Sanjay Garg
Journal:  Pharm Res       Date:  2012-06-01       Impact factor: 4.200

3.  A novel camptothecin derivative incorporated in nano-carrier induced distinguished improvement in solubility, stability and anti-tumor activity both in vitro and in vivo.

Authors:  Min Han; Cai-Xia He; Qiu-Li Fang; Xiao-Chun Yang; Yuan-Yuan Diao; Dong-Hang Xu; Qiao-Jun He; Yong-Zhou Hu; Wen-Quan Liang; Bo Yang; Jian-Qing Gao
Journal:  Pharm Res       Date:  2008-12-02       Impact factor: 4.200

4.  Biodistribution characteristics of galactosylated emulsions and incorporated probucol for hepatocyte-selective targeting of lipophilic drugs in mice.

Authors:  Emi Ishida; Chittima Managit; Shigeru Kawakami; Makiya Nishikawa; Fumiyoshi Yamashita; Mitsuru Hashida
Journal:  Pharm Res       Date:  2004-06       Impact factor: 4.200
  4 in total

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