Literature DB >> 11104837

3alpha-hydroxy-5alpha-pregnan-20-one exposure reduces GABA(A) receptor alpha4 subunit mRNA levels.

A C Grobin1, A L Morrow.   

Abstract

To examine the direct effects of neurosteroids on gamma-aminobutyric acid type A (GABA(A)) receptor expression, we exposed developing neuronal cells (P19) in vitro to 3alpha-hydroxy-5alpha-pregnan-20-one (3alpha,5alpha-THP, allopregnanolone). Quantitative reverse transcriptase-polymerase chain reaction (RT-PCR) analysis revealed a concentration-dependent decrease in GABA(A) receptor alpha4 subunit mRNA expression that reversed 24 h after steroid withdrawal. These data suggest that variations in neurosteroid levels regulate the pattern of GABA(A) receptor subunit expression and may alter the trophic effects of GABA.

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Year:  2000        PMID： 11104837     DOI： 10.1016/s0014-2999(00)00797-4

Source DB:  PubMed          Journal:  Eur J Pharmacol        ISSN： 0014-2999            Impact factor:   4.432


  7 in total

1.  Physiological doses of progesterone potentiate the effects of triazolam in healthy, premenopausal women.

Authors:  Shanna Babalonis; Joshua A Lile; Catherine A Martin; Thomas H Kelly
Journal:  Psychopharmacology (Berl)       Date:  2011-02-25       Impact factor: 4.530

Review 2.  Tolerance to allopregnanolone with focus on the GABA-A receptor.

Authors:  Sahruh Turkmen; Torbjorn Backstrom; Goran Wahlstrom; Lotta Andreen; Inga-Maj Johansson
Journal:  Br J Pharmacol       Date:  2011-01       Impact factor: 8.739

3.  Knockout of the γ-aminobutyric acid receptor subunit α4 reduces functional δ-containing extrasynaptic receptors in hippocampal pyramidal cells at the onset of puberty.

Authors:  Nicole Sabaliauskas; Hui Shen; Gregg E Homanics; Sheryl S Smith; Chiye Aoki
Journal:  Brain Res       Date:  2012-02-22       Impact factor: 3.252

4.  Steroid requirements for regulation of the alpha4 subunit of the GABA(A) receptor in an in vitro model.

Authors:  Xiangping Zhou; Sheryl S Smith
Journal:  Neurosci Lett       Date:  2006-11-01       Impact factor: 3.046

Review 5.  Neurosteroid regulation of GABA(A) receptors: Focus on the alpha4 and delta subunits.

Authors:  Sheryl S Smith; Hui Shen; Qi Hua Gong; Xiangping Zhou
Journal:  Pharmacol Ther       Date:  2007-04-21       Impact factor: 12.310

6.  Progesterone withdrawal increases the alpha4 subunit of the GABA(A) receptor in male rats in association with anxiety and altered pharmacology - a comparison with female rats.

Authors:  M Gulinello; Q H Gong; S S Smith
Journal:  Neuropharmacology       Date:  2002-09       Impact factor: 5.250

7.  Neurosteroids and GABA-A Receptor Function.

Authors:  Mingde Wang
Journal:  Front Endocrinol (Lausanne)       Date:  2011-10-04       Impact factor: 5.555
  7 in total

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