Literature DB >> 11104560

Most microsatellite unstable sporadic colorectal carcinomas carry MBD4 mutations.

S Bader1, M Walker, D Harrison.   

Abstract

The MBD4 gene is involved in the repair of mutation at methyl-CpG dinucleotides. In microsatellite unstable tumours MBD4 can itself be mutated at an exonic polynucleotide tract. By analysing DNA from microdissected tumour samples we have found that both frequency and pattern of mutation are more significant than originally reported. Copyright 2000 Cancer Research Campaign.

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Year:  2000        PMID： 11104560      PMCID： PMC2363466          DOI： 10.1054/bjoc.2000.1482

Source DB:  PubMed          Journal:  Br J Cancer        ISSN： 0007-0920            Impact factor:   7.640


  11 in total

1.  The mismatch repair and base excision repair pathways: an opportunity for individualized (personalized) sensitization of cancer therapy.

Authors:  Sean P Collins; Anatoly Dritschilo
Journal:  Cancer Biol Ther       Date:  2009-06-16       Impact factor: 4.742

2.  MBD4-mediated glycosylase activity on a chromatin template is enhanced by acetylation.

Authors:  Toyotaka Ishibashi; Kevin So; Claire G Cupples; Juan Ausió
Journal:  Mol Cell Biol       Date:  2008-06-02       Impact factor: 4.272

3.  The Roles of the Methyl-CpG Binding Proteins in Cancer.

Authors:  Lee Parry; Alan R Clarke
Journal:  Genes Cancer       Date:  2011-06

4.  Fas-associated death domain protein interacts with methyl-CpG binding domain protein 4: a potential link between genome surveillance and apoptosis.

Authors:  Robert A Screaton; Stephan Kiessling; Owen J Sansom; Catherine B Millar; Kathryn Maddison; Adrian Bird; Alan R Clarke; Steven M Frisch
Journal:  Proc Natl Acad Sci U S A       Date:  2003-04-17       Impact factor: 11.205

Review 5.  Participation of DNA repair in the response to 5-fluorouracil.

Authors:  M D Wyatt; D M Wilson
Journal:  Cell Mol Life Sci       Date:  2009-03       Impact factor: 9.261

6.  Production of truncated MBD4 protein by frameshift mutation in DNA mismatch repair-deficient cells enhances 5-fluorouracil sensitivity that is independent of hMLH1 status.

Authors:  Satoshi Suzuki; Moriya Iwaizumi; Stephanie Tseng-Rogenski; Yasushi Hamaya; Hiroaki Miyajima; Shigeru Kanaoka; Ken Sugimoto; John M Carethers
Journal:  Cancer Biol Ther       Date:  2016-04-26       Impact factor: 4.742

7.  A human cancer-associated truncation of MBD4 causes dominant negative impairment of DNA repair in colon cancer cells.

Authors:  S A Bader; M Walker; D J Harrison
Journal:  Br J Cancer       Date:  2007-02-06       Impact factor: 7.640

8.  Apoptosis and DNA methylation.

Authors:  Huan X Meng; James A Hackett; Colm Nestor; Donncha S Dunican; Monika Madej; James P Reddington; Sari Pennings; David J Harrison; Richard R Meehan
Journal:  Cancers (Basel)       Date:  2011-04-01       Impact factor: 6.639

9.  Epigenetics and colorectal cancer pathogenesis.

Authors:  Kankana Bardhan; Kebin Liu
Journal:  Cancers (Basel)       Date:  2013-06-05       Impact factor: 6.639

10.  MBD4 frameshift mutation caused by DNA mismatch repair deficiency enhances cytotoxicity by trifluridine, an active antitumor agent of TAS-102, in colorectal cancer cells.

Authors:  Satoshi Suzuki; Moriya Iwaizumi; Hidetaka Yamada; Tomohiro Sugiyama; Yasushi Hamaya; Takahisa Furuta; Shigeru Kanaoka; Haruhiko Sugimura; Hiroaki Miyajima; Satoshi Osawa; John M Carethers; Ken Sugimoto
Journal:  Oncotarget       Date:  2017-11-15
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