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Literature DB >> 11102873

Allosterically controllable ribozymes with biosensor functions.

Abstract

The concept of allosteric regulation has already been exploited in the creation of artificial ribozymes and the activities of certain ribozymes can be controlled allosterically by specific effectors. Ribozymes with such properties are in the spotlight as biosensors. Such artificial allosterically regulated ribozymes have potential utility as nucleic-acid-based biosensors.

Mesh：

Substances：
RNA, Catalytic

Year: 2000 PMID： 11102873 DOI： 10.1016/s1367-5931(00)00150-2

Source DB: PubMed Journal: Curr Opin Chem Biol ISSN： 1367-5931 Impact factor: 8.822

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Cited

6 in total

1. Significantly higher activity of a cytoplasmic hammerhead ribozyme than a corresponding nuclear counterpart: engineered tRNAs with an extended 3' end can be exported efficiently and specifically to the cytoplasm in mammalian cells.

Authors: T Kuwabara; M Warashina; S Koseki; M Sano; J Ohkawa; K Nakayama; K Taira
Journal: Nucleic Acids Res Date: 2001-07-01 Impact factor: 16.971

2. Measurements of weak interactions between truncated substrates and a hammerhead ribozyme by competitive kinetic analyses: implications for the design of new and efficient ribozymes with high sequence specificity.

Authors: Yasuhiro Kasai; Hideki Shizuku; Yasuomi Takagi; Masaki Warashina; Kazunari Taira
Journal: Nucleic Acids Res Date: 2002-06-01 Impact factor: 16.971

Allosterically controllable ribozymes with biosensor functions.

1. Significantly higher activity of a cytoplasmic hammerhead ribozyme than a corresponding nuclear counterpart: engineered tRNAs with an extended 3' end can be exported efficiently and specifically to the cytoplasm in mammalian cells.

2. Measurements of weak interactions between truncated substrates and a hammerhead ribozyme by competitive kinetic analyses: implications for the design of new and efficient ribozymes with high sequence specificity.

3. A versatile communication module for controlling RNA folding and catalysis.

Review 4. Nanozymes in Point-of-Care Diagnosis: An Emerging Futuristic Approach for Biosensing.

5. Nucleic acid evolution and minimization by nonhomologous random recombination.

6. In-silico design of computational nucleic acids for molecular information processing.