Literature DB >> 11102795

Small-molecule inhibitors of cell signaling.

F McCormick1.   

Abstract

Small-molecule inhibitors of several intracellular signaling proteins, mostly protein kinases, show tremendous selectivity and potency. The complexity and redundancy of signaling pathways presents opportunities for therapeutic selectivity and some clinical results are remarkable. New strategies are being developed to interfere with previously intractable targets, such as protein-protein interactions.

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Year:  2000        PMID： 11102795     DOI： 10.1016/s0958-1669(00)00149-x

Source DB:  PubMed          Journal:  Curr Opin Biotechnol        ISSN： 0958-1669            Impact factor:   9.740


  3 in total

1.  Molecular recognition of protein surfaces: high affinity ligands for the CBP KIX domain.

Authors:  Stacey E Rutledge; Heather M Volkman; Alanna Schepartz
Journal:  J Am Chem Soc       Date:  2003-11-26       Impact factor: 15.419

2.  An affinity-based fluorescence polarization assay for protein tyrosine phosphatases.

Authors:  Sheng Zhang; Lan Chen; Sanjai Kumar; Li Wu; David S Lawrence; Zhong-Yin Zhang
Journal:  Methods       Date:  2007-07       Impact factor: 3.608

3.  Structure-based discovery of an inhibitor of Arf activation by Sec7 domains through targeting of protein-protein complexes.

Authors:  Julien Viaud; Mahel Zeghouf; Hélène Barelli; Jean-Christophe Zeeh; André Padilla; Bernard Guibert; Pierre Chardin; Catherine A Royer; Jacqueline Cherfils; Alain Chavanieu
Journal:  Proc Natl Acad Sci U S A       Date:  2007-06-11       Impact factor: 11.205
  3 in total

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